Incidence rates of CVD/MI/stroke and major bleeding across different combinations of risk factors excluding prior bleeding
| Risk factors | Risk factor count | n | Events/100 person-years (95% CI) | |
| CVD/MI/stroke | Major bleeding | |||
| None | 0 | 16 863 | 1.9 (1.8 to 2) | 0.7 (0.6 to 0.7) |
| Age ≥65 | 1 | 14 111 | 3.8 (3.6 to 4) | 1.5 (1.4 to 1.6) |
| MVD+age ≥65 | 2 | 13 674 | 5.9 (5.6 to 6.1) | 1.9 (1.7 to 2) |
| MVD | 1 | 10 161 | 3 (2.8 to 3.1) | 0.7 (0.7 to 0.8) |
| MVD+CKD+age ≥65 | 3 | 5310 | 12.4 (11.8 to 12.9) | 2.7 (2.5 to 3) |
| CKD+age ≥65 | 2 | 4167 | 7.8 (7.4 to 8.3) | 2.4 (2.1 to 2.7) |
| MVD+prior MI+age ≥65 | 3 | 3483 | 10.9 (10.3 to 11.5) | 2.1 (1.9 to 2.4) |
| MVD+diabetes+age ≥65 | 3 | 2989 | 9.9 (9.2 to 10.6) | 2.1 (1.8 to 2.4) |
| MVD+CKD+prior MI+age ≥65 | 4 | 2141 | 18.3 (17.2 to 19.5) | 2.6 (2.3 to 3) |
| Diabetes+age ≥65 | 2 | 1893 | 5.9 (5.3 to 6.5) | 2.1 (1.7 to 2.5) |
| MVD+diabetes | 2 | 1891 | 5.5 (4.9 to 6) | 1.1 (0.9 to 1.4) |
| MVD+CKD+diabetes+age ≥65 | 4 | 1882 | 17.9 (16.7 to 19.2) | 3.1 (2.6 to 3.6) |
| Diabetes | 1 | 1811 | 3 (2.6 to 3.5) | 0.9 (0.7 to 1.1) |
| Prior MI+age ≥65 | 2 | 1771 | 7.4 (6.8 to 8.1) | 1.8 (1.5 to 2.1) |
| MVD+prior MI | 2 | 1522 | 6.2 (5.6 to 6.8) | 0.8 (0.6 to 1) |
| MVD+CKD+diabetes+prior MI+age ≥65 | 5 | 1283 | 25.9 (24 to 27.9) | 3.1 (2.6 to 3.8) |
| Prior MI | 1 | 1206 | 5.2 (4.6 to 5.8) | 1 (0.7 to 1.3) |
| CKD+diabetes+age ≥65 | 3 | 926 | 11.8 (10.5 to 13.2) | 2.5 (2 to 3.2) |
| CKD+prior MI+age ≥65 | 3 | 775 | 13 (11.6 to 14.5) | 2.3 (1.8 to 3) |
| CKD | 1 | 726 | 4.3 (3.5 to 5.1) | 1.1 (0.8 to 1.6) |
| MVD+diabetes+prior MI | 3 | 683 | 10.2 (8.9 to 11.5) | 1.3 (1 to 1.8) |
| MVD+CKD | 2 | 537 | 6.5 (5.4 to 7.8) | 1.2 (0.8 to 1.8) |
| Diabetes+prior MI+age ≥65 | 3 | 534 | 10.5 (9 to 12.2) | 2.5 (1.8 to 3.3) |
| Diabetes+prior MI | 2 | 359 | 8.2 (6.7 to 9.9) | 2.2 (1.5 to 3) |
| MVD+CKD+diabetes | 3 | 332 | 8.7 (7.1 to 10.7) | 1.9 (1.3 to 2.9) |
| CKD+diabetes+prior MI+age ≥65 | 4 | 316 | 19.2 (16.3 to 22.6) | 2.2 (1.4 to 3.3) |
| MVD+diabetes+prior MI+age ≥65 | 4 | 271 | 21.4 (17.9 to 25.5) | 3.2 (2.1 to 4.8) |
| CKD+diabetes | 2 | 174 | 6.9 (5 to 9.3) | 2.6 (1.6 to 4.2) |
| MVD+CKD+diabetes+prior MI | 4 | 161 | 22.7 (18.4 to 27.8) | 2.6 (1.5 to 4.2) |
| MVD+CKD+prior MI | 3 | 124 | 12.8 (9.6 to 16.7) | 2 (1 to 3.6) |
| CKD+prior MI | 2 | 87 | 6.2 (3.9 to 9.3) | 1.7 (0.7 to 3.5) |
| CKD+diabetes+prior MI | 3 | 50 | 8.6 (5 to 13.8) | 3.9 (1.7 to 7.6) |
CKD, chronic kidney disease; CVD, cardiovascular death; MI, myocardial infarction; MVD, multivessel disease.