Incidence rates of CVD/MI/stroke and major bleeding across different combinations including prior bleeding
| Risk factors | Risk factor count | n | Events/100 person-years (95% CI) | |
| CVD/MI/stroke | Major bleeding | |||
| Age ≥65+prior bleeding | 2 | 947 | 6.5 (5.6 to 7.5) | 3.9 (3.2 to 4.6) |
| MVD+age ≥65+prior bleeding | 3 | 941 | 9.3 (8.2 to 10.5) | 4.1 (3.4 to 4.9) |
| MVD+CKD+age ≥65+prior bleeding | 4 | 574 | 17.1 (15 to 19.4) | 4.9 (3.9 to 6.2) |
| Prior bleeding | 1 | 523 | 3.8 (3 to 4.8) | 2.4 (1.7 to 3.2) |
| MVD+prior MI+age ≥65+prior bleeding | 4 | 472 | 15.1 (13 to 17.4) | 4.7 (3.7 to 6) |
| MVD+CKD+prior MI+age ≥65+prior bleeding | 5 | 403 | 24.7 (21.5 to 28.2) | 3.7 (2.6 to 5) |
| CKD+age ≥65+prior bleeding | 3 | 396 | 13.9 (11.7 to 16.4) | 5.4 (4 to 7) |
| MVD+prior bleeding | 2 | 329 | 4.8 (3.7 to 6.2) | 3.5 (2.6 to 4.7) |
| MVD+diabetes+prior MI+age ≥65+prior bleeding | 5 | 271 | 21.4 (17.9 to 25.5) | 3.2 (2.1 to 4.8) |
| MVD+CKD+diabetes+prior MI+age ≥65+prior bleeding | 6 | 270 | 28.4 (23.9 to 33.4) | 5.2 (3.6 to 7.3) |
| MVD+CKD+diabetes+age ≥65+prior bleeding | 5 | 264 | 22.6 (18.7 to 27.1) | 7.9 (5.7 to 10.6) |
| Diabetes+age ≥65+prior bleeding | 3 | 215 | 6.4 (4.6 to 8.7) | 5.8 (4.1 to 8.1) |
| Prior MI+age ≥65+prior bleeding | 3 | 215 | 11.3 (8.9 to 14.2) | 4.9 (3.4 to 6.7) |
| CKD+prior MI+age ≥65+prior bleeding | 4 | 155 | 15.6 (12.1 to 19.8) | 5.9 (3.9 to 8.6) |
| MVD+diabetes+prior bleeding | 3 | 136 | 8.1 (5.7 to 11.2) | 2.6 (1.4 to 4.5) |
| Diabetes+prior bleeding | 2 | 122 | 5.6 (3.7 to 8.2) | 3.1 (1.8 to 5.1) |
| MVD+prior MI+prior bleeding | 3 | 121 | 7.1 (4.9 to 10.1) | 2.6 (1.4 to 4.5) |
| CKD+diabetes+age ≥65+prior bleeding | 4 | 117 | 15.4 (11.1 to 20.7) | 5.2 (3 to 8.5) |
| Prior MI+prior bleeding | 2 | 89 | 7.4 (4.9 to 10.8) | 3.3 (1.8 to 5.6) |
| MVD+diabetes+prior MI+prior bleeding | 4 | 86 | 14.1 (10.1 to 19.2) | 4 (2.2 to 6.8) |
| MVD+diabetes+age ≥65+prior bleeding | 4 | 86 | 14.1 (10.1 to 19.2) | 4 (2.2 to 6.8) |
| CKD+diabetes+prior MI+age ≥65+prior bleeding | 5 | 76 | 20.5 (13.9 to 29.1) | 5.1 (2.4 to 9.6) |
| Diabetes+prior MI+age ≥65+prior bleeding | 4 | 70 | 13.4 (8.7 to 19.8) | 4.2 (2 to 7.9) |
| MVD+CKD+diabetes+prior bleeding | 4 | 54 | 23.4 (15.4 to 34.3) | 8.7 (4.6 to 15.1) |
| CKD+prior bleeding | 2 | 52 | 5.6 (2.8 to 10.3) | 3.6 (1.5 to 7.4) |
| MVD+CKD+prior bleeding | 3 | 49 | 11.1 (6.7 to 17.3) | 4.3 (1.9 to 8.4) |
| MVD+CKD+diabetes+prior MI+prior bleeding | 5 | 43 | 22.1 (14.4 to 32.6) | 5.2 (2.3 to 10.2) |
| MVD+CKD+prior MI+prior bleeding | 4 | 32 | 10.8 (5.1 to 20.3) | 0 (0 to 2.9) |
| Diabetes+prior MI+prior bleeding | 3 | 31 | 11.3 (6 to 19.6) | 2.6 (0.7 to 6.9) |
| CKD+diabetes+prior bleeding | 3 | 27 | 10.7 (5 to 20.2) | 7 (2.7 to 15.3) |
| CDK+prior MI+prior bleeding | 3 | 17 | 9.5 (3.6 to 20.8) | 3.8 (0.8 to 12.1) |
| CKD+diabetes+prior MI+prior bleeding | 4 | 12 | 52 (26.7 to 92.2) | 3.7 (0.3 to 17.4) |
CKD, chronic kidney disease; CVD, cardiovascular death; MI, myocardial infarction; MVD, multivessel disease.