Table 4

Incidence rates of CVD/MI/stroke and major bleeding across different combinations including prior bleeding

Risk factorsRisk
factor
count
nEvents/100 person-years
(95% CI)
CVD/MI/strokeMajor bleeding
Age ≥65+prior bleeding29476.5 (5.6 to 7.5)3.9 (3.2 to 4.6)
MVD+age ≥65+prior bleeding39419.3 (8.2 to 10.5)4.1 (3.4 to 4.9)
MVD+CKD+age ≥65+prior bleeding457417.1 (15 to 19.4)4.9 (3.9 to 6.2)
Prior bleeding15233.8 (3 to 4.8)2.4 (1.7 to 3.2)
MVD+prior MI+age ≥65+prior bleeding447215.1 (13 to 17.4)4.7 (3.7 to 6)
MVD+CKD+prior MI+age ≥65+prior bleeding540324.7 (21.5 to 28.2)3.7 (2.6 to 5)
CKD+age ≥65+prior bleeding339613.9 (11.7 to 16.4)5.4 (4 to 7)
MVD+prior bleeding23294.8 (3.7 to 6.2)3.5 (2.6 to 4.7)
MVD+diabetes+prior MI+age ≥65+prior bleeding527121.4 (17.9 to 25.5)3.2 (2.1 to 4.8)
MVD+CKD+diabetes+prior MI+age ≥65+prior bleeding627028.4 (23.9 to 33.4)5.2 (3.6 to 7.3)
MVD+CKD+diabetes+age ≥65+prior bleeding526422.6 (18.7 to 27.1)7.9 (5.7 to 10.6)
Diabetes+age ≥65+prior bleeding32156.4 (4.6 to 8.7)5.8 (4.1 to 8.1)
Prior MI+age ≥65+prior bleeding321511.3 (8.9 to 14.2)4.9 (3.4 to 6.7)
CKD+prior MI+age ≥65+prior bleeding415515.6 (12.1 to 19.8)5.9 (3.9 to 8.6)
MVD+diabetes+prior bleeding31368.1 (5.7 to 11.2)2.6 (1.4 to 4.5)
Diabetes+prior bleeding21225.6 (3.7 to 8.2)3.1 (1.8 to 5.1)
MVD+prior MI+prior bleeding31217.1 (4.9 to 10.1)2.6 (1.4 to 4.5)
CKD+diabetes+age ≥65+prior bleeding411715.4 (11.1 to 20.7)5.2 (3 to 8.5)
Prior MI+prior bleeding2897.4 (4.9 to 10.8)3.3 (1.8 to 5.6)
MVD+diabetes+prior MI+prior bleeding48614.1 (10.1 to 19.2)4 (2.2 to 6.8)
MVD+diabetes+age ≥65+prior bleeding48614.1 (10.1 to 19.2)4 (2.2 to 6.8)
CKD+diabetes+prior MI+age ≥65+prior bleeding57620.5 (13.9 to 29.1)5.1 (2.4 to 9.6)
Diabetes+prior MI+age ≥65+prior bleeding47013.4 (8.7 to 19.8)4.2 (2 to 7.9)
MVD+CKD+diabetes+prior bleeding45423.4 (15.4 to 34.3)8.7 (4.6 to 15.1)
CKD+prior bleeding2525.6 (2.8 to 10.3)3.6 (1.5 to 7.4)
MVD+CKD+prior bleeding34911.1 (6.7 to 17.3)4.3 (1.9 to 8.4)
MVD+CKD+diabetes+prior MI+prior bleeding54322.1 (14.4 to 32.6)5.2 (2.3 to 10.2)
MVD+CKD+prior MI+prior bleeding43210.8 (5.1 to 20.3)0 (0 to 2.9)
Diabetes+prior MI+prior bleeding33111.3 (6 to 19.6)2.6 (0.7 to 6.9)
CKD+diabetes+prior bleeding32710.7 (5 to 20.2)7 (2.7 to 15.3)
CDK+prior MI+prior bleeding3179.5 (3.6 to 20.8)3.8 (0.8 to 12.1)
CKD+diabetes+prior MI+prior bleeding41252 (26.7 to 92.2)3.7 (0.3 to 17.4)
  • CKD, chronic kidney disease; CVD, cardiovascular death; MI, myocardial infarction; MVD, multivessel disease.