Cox regression for absolute NT-proBNP levels at discharge and 6-month all-cause mortality
| HFpEF (EF ≥50%) | HFrEF (EF <40%) | |||
| Univariable model HR (95% CI) | Multivariable model* HR (95% CI) | Univariable model HR (95% CI) | Multivariable model* HR (95% CI) | |
| NT-proBNP levels at discharge, pg/mL | ||||
| NT-proBNP ≤1000 | 1 | 1 | 1 | 1 |
| NT-proBNP 1001–3000 | 6.59 (0.87 to 49.83) | 1 | 1.13 (0.40 to 3.16) | 1 |
| NT-proBNP 3001–9000 | 7.73 (0.97 to 61.33) | 1.38 (0.58 to 3.27) | 2.52 (0.98 to 6.47) | 1.61 (0.90 to 2.88) |
| NT-proBNP >9000 | 29.50 (3.74 to 232.87) | 5.68 (2.24 to 14.36) | 9.21 (3.68 to 23.00) | 4.79 (2.76 to 8.33) |
| Cox regression for absolute NT-proBNP levels at discharge and the composite endpoint of 6-month cardiovascular readmission/all-cause mortality | ||||
| NT-proBNP levels at discharge, pg/mL | ||||
| NT-proBNP ≤1000 | 1 | 1 | 1 | 1 |
| NT-proBNP 1001–3000 | 1.62 (0.93 to 2.85) | 1 | 1.17 (0.75 to 1.81) | 1 |
| NT-proBNP 3001–9000 | 2.04 (1.13 to 3.69) | 1.29 (0.82 to 2.02) | 1.89 (1.26 to 2.85) | 1.40 (1.06 to 1.86) |
| NT-proBNP >9000 | 3.13 (1.58 to 6.17) | 1.81 (0.98 to 3.33) | 3.21 (2.11 to 4.89) | 2.21 (1.63 to 3.01) |
*Adjusted for age ≥75 years, peripheral oedema, systolic blood pressure ≤115 mm Hg, hyponatraemia (sodium level <135 mmol/L), serum urea ≥15 mmol/L.
EF, ejection fraction; HFpEF, heart failure with preserved ejection fraction; HFrEF, heart failure with reduced ejection fraction; NT-proBNP, N-terminal pro-B-type natriuretic peptide.