Association of low SAC with outcomes in asymptomatic aortic stenosis in univariable and multivariable Cox analyses
| Event | Univariable analysis | Multivariable model 1 | Multivariable model 2 | Multivariable model 3 | Multivariable model 4 | |||||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| Cardiovascular death (n=78) | 2.49 (1.64 to 3.78) | <0.001 | 2.13 (1.34 to 3.40) | 0.001 | 2.28 (1.28 to 4.06) | 0.005 | 2.01 (1.22 to 3.30) | 0.003 | 1.86 (1.12 to 3.11) | 0.017 |
| All-cause mortality (n=153) | 2.00 (1.48 to 2.71) | <0.001 | 1.71 (1.23 to 2.38) | 0.001 | 1.72 (1.15 to 2.58) | 0.009 | 1.63 (1.14 to 2.32) | 0.006 | 1.64 (1.14 to 2.34) | 0.007 |
All models were run with aortic valve replacement as a competing event and adjusted for randomised lipid-lowering study treatment, AS severity by mean aortic gradient, obesity, age, sex, presence of a small aortic root and antihypertensive treatment. Model 2 also adjusted for aortic valve area, model 3 also for dimensionless index and model 4 also for the presence of inconsistently graded AS.
SAC, systemic arterial compliance.