Baseline characteristics for overall cohort and according to high-sensitivity cardiac troponin I and BNP quantiles (below/above median)
| Overall N=885 | hs-cTnI | BNP | |||||
| Low (≤1.4 ng/L) n=443 | High (>1.4 ng/L) n=442 | P value | Low (≤29.1 ng/L) n=443 | High (>29.1 ng/L) n=442 | P value | ||
| Male | 494 (55.8) | 192 (43.3) | 302 (68.3) | <0.001 | 267 (60.3) | 227 (51.4) | 0.009 |
| Age | 59.0 (51.0–65.0) | 55.0 (48.0–63.0) | 62.0 (55.0–67.0) | <0.001 | 55.0 (48.0–62.0) | 62.0 (55.0–67.0) | <0.001 |
| Hypertension | 325 (36.7) | 119 (26.9) | 206 (46.6) | <0.001 | 149 (33.6) | 176 (39.8) | 0.07 |
| Hyperlipidaemia | 528 (59.7) | 246 (55.5) | 282 (63.8) | 0.015 | 233 (52.6) | 295 (66.7) | <0.001 |
| Diabetes | 91 (10.3) | 41 (9.3) | 50 (11.3) | 0.37 | 50 (11.3) | 41 (9.3) | 0.38 |
| Known CAD | 77 (8.7) | 24 (5.4) | 53 (12.0) | 0.001 | 23 (5.2) | 54 (12.2) | <0.001 |
| Family history of CAD | 383 (43.3) | 214 (48.3) | 169 (38.2) | 0.003 | 199 (44.9) | 184 (41.6) | 0.36 |
| Smoking history | |||||||
| Non-smoker | 396 (44.7) | 192 (43.3) | 204 (46.2) | 0.009 | 203 (45.8) | 193 (43.7) | 0.07 |
| Ex-smoker | 313 (35.4) | 145 (32.7) | 168 (38.0) | 142 (32.1) | 171 (38.7) | ||
| Current smoker | 176 (19.9) | 106 (23.9) | 70 (15.8) | 98 (22.1) | 78 (17.6) | ||
| Atrial fibrillation | 14 (1.6) | 6 (1.4) | 8 (1.8) | 0.78 | 8 (1.8) | 6 (1.4) | 0.79 |
| Cerebrovascular disease | 38 (4.3) | 18 (4.1) | 20 (4.5) | 0.87 | 16 (3.6) | 22 (5.0) | 0.40 |
| PVD | 17 (1.9) | 8 (1.8) | 9 (2.0) | 1.00 | 7 (1.6) | 10 (2.3) | 0.63 |
| Chest pain type | |||||||
| Non-anginal | 303 (34.2) | 179 (40.4) | 124 (28.1) | <0.001 | 183 (41.3) | 120 (27.1) | <0.001 |
| Atypical angina | 211 (23.8) | 119 (26.9) | 92 (20.8) | 108 (24.4) | 103 (23.3) | ||
| Typical angina | 371 (41.9) | 145 (32.7) | 226 (51.1) | 152 (34.3) | 219 (49.5) | ||
| Systolic blood pressure (mm Hg) | 140.0 (128.0–154.0) | 138.0 (124.0–151.0) | 140.0 (130.0–156.8) | <0.001 | 140.0 (128.0–152.0) | 140.0 (128.0–155.0) | 0.30 |
| Diastolic blood pressure (mm Hg) | 81.0 (76.0–90.0) | 80.0 (75.0–90.0) | 82.0 (76.0–90.0) | 0.04 | 82.0 (77.0–90.0) | 80.0 (75.0–90.0) | 0.12 |
| BMI (kg/m2) | 28.7 (25.9–32.6) | 28.6 (25.5–32.3) | 29.0 (26.2–32.9) | 0.13 | 29.1 (26.3–33.3) | 28.2 (25.5–32.2) | 0.02 |
| Antiplatelet | 448 (50.6) | 189 (42.7) | 259 (58.6) | <0.001 | 183 (41.3) | 265 (60.0) | <0.001 |
| Statin | 393 (44.4) | 171 (38.6) | 222 (50.2) | 0.001 | 158 (35.7) | 235 (53.2) | <0.001 |
| ACE inhibitor | 123 (13.9) | 40 (9.0) | 83 (18.8) | <0.001 | 48 (10.8) | 75 (17.0) | 0.01 |
| Beta-blocker | 202 (22.8) | 84 (19.0) | 118 (26.7) | 0.008 | 72 (16.3) | 130 (29.4) | <0.001 |
| ASSIGN score | 16.0 (10.0–23.0) | 13.0 (8.0–21.0) | 18.0 (13.0–26.0) | <0.001 | 14.0 (9.0–22.0) | 17.0 (12.0–25.0) | <0.001 |
| Creatinine (µmol/L) | 91.1 (76.7–109.5) | 88.6 (74.4–106.3) | 93.5 (79.6–111.7) | <0.001 | 91.4 (77.4–111.4) | 90.6 (76.5–108.2) | 0.3 |
| hs-cTnI (ng/L) | 1.3 (0.9–2.1) | 0.9 (0.7–1.1) | 2.1 (1.6–3.2) | <0.001 | 1.2 (0.8–1.8) | 1.5 (1.0–2.4) | <0.001 |
| BNP (ng/L) | 29.1 (14.2–54.0) | 24.9 (11.2–44.1) | 34.9 (19.2–67.1) | <0.001 | 14.2 (7.8–21.7) | 54.1 (39.6–83.8) | <0.001 |
| CAD | |||||||
| Normal | 309 (34.9) | 204 (46.0) | 105 (23.8) | <0.001 | 178 (40.2) | 131 (29.6) | <0.001 |
| Mild (<50%) | 175 (19.8) | 88 (19.9) | 87 (19.7) | 94 (21.2) | 81 (18.3) | ||
| Moderate (50%–70%) | 159 (18.0) | 77 (17.4) | 82 (18.6) | 76 (17.2) | 83 (18.8) | ||
| Obstructive (>70%) | 242 (27.3) | 74 (16.7) | 168 (38.0) | 95 (21.4) | 147 (33.3) | ||
| CT-adapted Leaman score | 4.0 (0.0–10.9) | 1.5 (0.0–6.9) | 7.0 (0.9–14.4) | <0.001 | 3.1 (0.0–8.7) | 5.5 (0.0–12.2) | <0.001 |
| Calcium score (Agatston units) | 30.0 (0.0–269.0) | 3.0 (0.0–95.0) | 103.5 (1.2–546.5) | <0.001 | 11.0 (0.0–136.5) | 63.5 (0.0–430.2) | <0.001 |
| Indexed left ventricular volume (mL/m2) | 63.2 (56.6–69.5) | 63.2 (57.2–69.6) | 62.5 (55.8–69.3) | 0.30 | 62.6 (56.2–69.7) | 63.2 (56.9–69.4) | 0.72 |
| Indexed left ventricular mass (g/m2) | 71.7 (62.6–81.5) | 67.6 (59.6–76.8) | 75.7 (67.6–84.4) | <0.001 | 72.6 (63.4–81.7) | 70.8 (61.6–81.2) | 0.17 |
| Left ventricular hypertrophy | 404 (45.6) | 174 (39.3) | 230 (52.0) | <0.001 | 203 (45.8) | 201 (45.5) | 0.97 |
Continuous variables are presented as median (IQR).
Categorical variables are presented as n (%).
BMI, body mass index; BNP, B-type natriuretic peptide; CAD, coronary artery disease; CTCA, CT coronary angiography; hs-cTnI, high-sensitivity cardiac troponin I; PVD, peripheral vascular disease.