Table 4

Region-specific HRs (95% CIs) for incident chronic disease according to two famine exposure subgroups

	Rural areas (n=50 202)		Urban areas (n=42 082)		P_interaction
	Non-famine births	Famine births	Non-famine births	Famine births	P_interaction
No of participants	40 288	9914	32 202	9880
Ischaemic heart disease					0.041
Cases	1754	478	1721	673
Cases/PYs (/1000)	4.3	4.8	5.4	7.0
HRs (95% CIs)	1.00	1.07 (0.96 to 1.19)	1.00	1.20 (1.09 to 1.32)
Major coronary events					0.622
Cases	208	64	182	61
Cases/PYs (/1000)	0.5	0.6	0.6	0.6
HRs (95% CIs)	1.00	1.24 (0.92 to 1.66)	1.00	1.08 (0.80 to 1.47)
Cerebrovascular disease					<0.001
Cases	3235	827	2344	926
Cases/PYs (/1000)	8.0	8.4	7.4	9.7
HRs (95% CIs)	1.00	1.04 (0.96 to 1.13)	1.00	1.18 (1.09 to 1.28)
Ischaemic stroke					0.001
Cases	1531	391	1495	589
Cases/PYs (/1000)	3.7	3.9	4.7	6.1
HRs (95% CIs)	1.00	1.04 (0.92 to 1.16)	1.00	1.18 (1.07 to 1.31)
Haemorrhagic stroke					0.176
Cases	455	118	175	68
Cases/PYs (/1000)	1.1	1.2	0.5	0.7
HRs (95% CIs)	1.00	1.00 (0.81 to 1.23)	1.00	1.22 (0.91 to 1.64)
Cancer					0.361
Cases	1221	315	1210	365
Cases/PYs (/1000)	3.0	3.1	3.8	3.7
HRs (95% CIs)	1.00	1.07 (0.94 to 1.22)	1.00	0.97 (0.86 to 1.10)
Respiratory system disease					0.056
Cases	9764	2764	2051	626
Cases/PYs (/1000)	29.0	34.5	6.8	6.7
HRs (95% CIs)	1.00	1.10 (1.06 to 1.15)	1.00	0.95 (0.87 to 1.05)
COPD					0.149
Cases	595	138	96	38
Cases/PYs (/1000)	1.5	1.4	0.3	0.4
HRs (95% CIs)	1.00	0.99 (0.82 to 1.20)	1.00	1.29 (0.87 to 1.93)

Multivariable model was adjusted for the same set of covariates as in model 3 of table 2.
COPD, chronic obstructive pulmonary disease; PYs, person-years.