Table 1

Summary of meta-analysis for the association of LA dimensions and risk of cardiovascular outcomes

LA echocardiographic parameterOutcomes
Stroke and thromboembolic eventsHeart failureAll-cause mortalityMajor adverse cardiac events
Patients with AFPatients without AFPatients with AFPatients without AFPatients with AFPatients without AFPatients with AFPatients without AF
LA diameter
 Included studies, n63221617
 Patients, n42335431336211516262391482620
 Events, n3182756622235113035369
 RR (95% CI)1.02 (0.98 to 1.07)1.38 (1.02 to 1.87)1.07 (1.03 to 1.11)1.05 (1.03 to 1.07)1.05 (0.99 to 1.12)1.29 (1.08 to 1.54)1.74 (1.09 to 2.77)1.34 (1.18 to 1.52)
 P value0.270.03<0.001<0.0010.130.0050.02<0.001
 I2 value, %4985130NA78NA87
 P for difference0.050.310.030.28
LA diameter index
 Included studies, n21000013
 Patients, n407431300002981265
 Events, n25447000035113
 RR (95% CI)1.07 (1.04 to 1.10)1.11 (1.00 to 1.22)NRNRNRNR1.13 (1.09 to 1.17)2.98 (1.90 to 4.66)
 P value<0.0010.04<0.001<0.001
 I2 value, %25NANANANANANA0
 P for difference0.49NANA<0.001
LA volume
 Included studies, n10010201
 Patients, n1361001495011330108
 Events, n100001380313031
 RR (95% CI)1.00 (1.00 to 1.00)NRNR1.02 (1.01 to 1.02)NR1.02 (1.01 to 1.03)NR1.05 (1.03 to 1.08)
 P value0.32<0.0010.005<0.001
 I2 value, %NANANANANANANANA
 P for differenceNANANANA
LA volume index
 Included studies, n6326112321
 Patients, n31971380708528697178646739695
 Events, n209139904468911741231728
 RR (95% CI)1.02 (1.00 to 1.04)1.22 (0.94 to 1.59)1.11 (0.95 to 1.29)1.07 (1.03 to 1.10)1.10 (0.78 to 1.55)1.05 (1.02 to1.07)1.01 (1.00 to 1.02)1.08 (1.05 to 1.10)
 P value0.120.130.18<0.0010.59<0.0010.03<0.001
 I2 value, %73728975NA80088
 P for difference0.170.630.78<0.001
  • P for difference represents the difference of pooled RR between AF and non-AF studies. NR indicates not reported.

  • AF, atrial fibrillation; LA, left atrial; NA, not applicable; RR, risk ratio.