Table 1

Characteristics of SCD individuals and families with and without premature atherosclerosis

Sudden cardiac arrest onlySudden cardiac arrest and premature atherosclerosis
250 families190 families
Number of Ajmaline tested family members±SD1.76±1.841.90±2.20
Number of SCD cases per family, mean±SD1.63±1.152.34±1.47*
Age of youngest SCD case in the family, mean±SD36.23±1.4742.06±11.04*
Families with youngest SCD case >45 years, n (%)63 (25, 20–31)79 (42, 35–49)*
Families with positive Ajmaline test47 (19, 14–24)41 (22, 16–28)
Youngest SCD case >45 years and positive Ajmaline test, n (%)40 (16, 12–21)30 (16, 11–22)
428 individuals374 individuals
HR <60 bpm before Ajmaline, n (%)150 (35, 31–40)150 (40, 35–45)
HR <60 bpm after Ajmaline, n (%)30 (7, 5–10)26 (7, 5–10)
PQ >200 ms after Ajmaline, n (%)154 (36, 32–41)134 (36, 31–41)
QRS >120 ms after Ajmaline, n (%)98 (23, 19–27)82 (22, 18–26)
44 families36 families
Families with pathogenic SCN5A mutation, n (%)8 (18, 10–32)1 (3, 1–14)*
  • Continuous variables are expressed as mean±SD, dichotomous variables are expressed as N (%—95% CI for proportion).

  • *P<0.05.

  • HR, heart rate; PAS, premature atherosclerosis; SCD, sudden cardiac death.