Characteristics of all Ajmaline positive tested individuals divided by pathogenic SCN5A mutation.
| Pathogenic SCN5A mutation | No SCN5A mutation | |
| 9 Families | 71 Families | |
| SCD families with youngest case >45 years (%) | 0 (0, 0–30) | 28 (39, 29–51)* |
| Families with >1 SCD case (%) | 1 (11, 2–44) | 48 (68, 56–77)* |
| Families with PAS | 1 (11, 2–44) | 35 (49, 38–61)* |
| 9 Individuals | 103 Individuals | |
| HR <60 bpm before Ajmaline, n (%) | 3 (33, 12–65) | 33 (32, 24–42) |
| HR <60 bpm after Ajmaline, n, (%) | 0 (0, 0–29) | 10 (10, 5–17) |
| PQ >200 ms after Ajmaline, n (%) | 1 (11, 2–44) | 24 (23, 16–32) |
| QRS >120 ms after Ajmaline, n (%) | 1 (11, 2–44) | 12 (12, 7–19) |
Variables are expressed as N (%—95% CI for proportion).
*P<0.05.
HR, heart rate; PAS, premature atherosclerosis; SCD, sudden cardiac death.