Risk scores and assessment of coronary artery disease (CAD) likelihood by WHO body mass index categories and presence of obstructive CAD by invasive angiography or CT angiography
| Underweight (n=56) | Normal (n=1459) | Overweight (n=3135) | Obese 1 (n=2463) | Obese 2 (n=1170) | Obese 3 (n=606) | P value | |
| 10-year CVD risk | |||||||
| Framingham Risk Score (2008) | <0.001 | ||||||
| Mean (SD) | 15.5 (11.80) | 18.0 (13.40) | 20.9 (14.29) | 23.6 (15.82) | 22.6 (15.80) | 22.7 (14.96) | |
| Low risk (<10%) | 15/56 (26.8) | 484/1457 (33.2) | 726/3134 (23.2) | 434/2461 (17.6) | 245/1168 (21.0) | 104/606 (17.2) | <0.001 |
| Intermediate risk (10%–20%) | 28/56 (50.0) | 500/1457 (34.3) | 1139/3134 (36.3) | 857/2461 (34.8) | 410/1168 (35.1) | 227/606 (37.5) | 0.128 |
| High risk (>20%) | 13/56 (23.2) | 473/1457 (32.5) | 1269/3134 (40.5) | 1170/2461 (47.5) | 513/1168 (43.9) | 275/606 (45.4) | <0.001 |
| Likelihood of CAD | |||||||
| Diamond and Forrester (2011) | <0.001 | ||||||
| Mean (SD) | 35.3 (17.41) | 39.2 (18.29) | 42.4 (18.16) | 41.1 (18.39) | 38.8 (18.09) | 37.0 (17.82) | |
| Low risk (<30%) | 32/56 (57.1) | 658/1459 (45.1) | 1091/3135 (34.8) | 974/2463 (39.5) | 544/1170 (46.5) | 314/606 (51.8) | <0.001 |
| Intermediate risk (30%–70%) | 23/56 (41.1) | 729/1459 (50.0) | 1860/3135 (59.3) | 1353/2463 (54.9) | 564/1170 (48.2) | 261/606 (43.1) | <0.001 |
| High risk (>70%) | 1/56 (1.8) | 72/1459 (4.9) | 184/3135 (5.9) | 136/2463 (5.5) | 62/1170 (5.3) | 31/606 (5.1) | 0.628 |
| Physician’s estimation of likelihood of significant CAD | <0.001 | ||||||
| Very low (<10%) | 6/56 (10.7) | 105/1455 (7.2) | 216/3130 (6.9) | 135/2461 (5.5) | 64/1170 (5.5) | 31/606 (5.1) | |
| Low (10%–30%) | 17/56 (30.4) | 502/1455 (34.5) | 1014/3130 (32.4) | 762/2461 (31.0) | 350/1170 (29.9) | 170/606 (28.1) | |
| Intermediate (31%–70%) | 32/56 (57.1) | 784/1455 (53.9) | 1772/3130 (56.6) | 1442/2461 (58.6) | 690/1170 (59.0) | 365/606 (60.2) | |
| High (71%–90%) | 1/56 (1.8) | 60/1455 (4.1) | 123/3130 (3.9) | 112/2461 (4.6) | 64/1170 (5.5) | 33/606 (5.4) | |
| Very high (>90%) | 0/56 (0.0) | 4/1455 (0.3) | 5/3130 (0.2) | 10/2461 (0.4) | 2/1170 (0.2) | 7/606 (1.2) | |
| Obstructive CAD | |||||||
| Obstructive CAD by CTA or Cath | 2/29 (6.9) | 104/764 (13.6) | 230/1743 (13.2) | 205/1326 (15.5) | 70/631 (11.1) | 37/332 (11.1) | 0.067 |
| Obstructive CAD by CTA | 0/26 (0.0) | 73/707 (10.3) | 178/1627 (10.9) | 161/1229 (13.1) | 48/581 (8.3) | 27/291 (9.3) | 0.013 |
| Obstructive CAD by Cath | 2/4 (50.0) | 73/131 (55.7) | 170/317 (53.6) | 142/251 (56.6) | 58/110 (52.7) | 21/68 (30.9) | 0.010 |
Data are n/N (%) except where indicated.
CTA, computed tomographic angiography; CVD, cardiovascular disease; 90 days of randomization Cath, invasive coronary angiography.