Table 1

Clinical interpretation and generalised characterisation of the six phenogroups

Phenogroup (n)Generalised characteristicsPrimary events per 100 patient-years*
1 (n=30)Younger, risk factors such as hypertension, CAD and diabetes, larger left ventricular volumes, and CKD33
2 (n=40)Older, less hypertrophy but worse left ventricular and right ventricular systolic function and more severe HF, and notably high prevalence of COPD40
3 (n=48)Younger, male, obesity, less left and right diastolic and systolic function, and milder HF11
4 (n=52)Male, hypertension, left ventricular hypertrophy, left atrial enlargement and AF19
5 (n=101)Older, female, hypertension, CAD, large left side but good right ventricular function21
6 (n=49)Older, female, low BMI, hypertension, AF and right-sided failure27
  • *Derived from events to mid-term time point at 18 months.

  • AF, atrial fibrillation; BMI, body mass index; CAD, coronary artery disease; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; HF, heart failure.