Table 3

HRs of outcome in association with gender, age and comorbidities in univariable and multivariable Cox proportional hazard regression models

VariableIschaemic strokeHaemorrhagic strokeAcute myocardial infarction
Crude HR (95% CI)Adjusted HR† (95% CI)Crude HR (95% CI)Adjusted HR† (95% CI)Crude HR (95% CI)Adjusted HR† (95% CI)
Age1.05 (1.04 to 1.05)***1.05(1.04,1 .05)***1.03 (1.02,1.04)***1.02 (1.01 to 1.03)***1.04 (1.03 to 1.05)***1.04 (1.03 to 1.05)***
Sex1.30 (1.19 to 1.43)***1.36 (1.24 to 1.50)***1.53 (1.26 to 1.85)***1.44 (1.17 to 1.77)***1.98 (1.63 to 2.40)***2.09 (1.70 to 2.57)***
Monthly income (NTD)†      
 <15 0001.34 (1.20 to 1.49)***1.13 (1.00 to 1.28)1.84 (1.44 to 2.34)***1.60 (1.22 to 2.09)***1.40 (1.13 to 1.74)**1.05 (0.81 to 1.35)
 15 000–19 9991.22 (1.08 to 1.37)**1.38 (1.22 to 1.57)***1.84 (1.43 to 2.37)***1.94 (1.49 to 2.54)***1.05 (0.82 to 1.35)1.17 (0.90 to 1.53)
 ≥20 0001(Reference)1(Reference)1(Reference)1(Reference)1(Reference)1(Reference)
Urbanisation level      
 1 (highest)1(Reference)1(Reference)1(Reference)1(Reference)1(Reference)1(Reference)
 21.14 (1.00 to 1.30)* 1.14 (1.00 to 1.30)0.90 (0.69 to 1.18)1.07 (0.82 to 1.40)1.25 (0.96 to 1.62)1.01 (0.77 to 1.31)
 31.14 (0.98 to 1.33)1.20 (1.03 to 1.39)* 1.14 (0.85 to 1.53)1.10 (0.81 to 1.51)1.36 (1.01 to 1.82)* 0.96 (0.70 to 1.32)
 4 (lowest)1.49 (1.32 to 1.68)***1.30 (1.14 to 1.49)***1.05 (0.81 to 1.35)1.10 (0.83 to 1.45)1.18 (0.91 to 1.53)0.92 (0.70 to 1.22)
Comorbidity      
 Diabetes2.71 (2.43 to 3.02)***2.22 (1.97 to 2.49)***1.44 (1.09 to 1.92)* 1.43 (1.07 to 1.91)* 2.83 (2.24 to 3.58)***2.71 (2.12 to 3.47)***
 Hypertension2.47 (2.20 to 2.79)***1.60 (1.41 to 1.82)***2.46 (1.91 to 3.15)***2.08 (1.58 to 2.72)***2.18 (1.73 to 2.74)***1.40 (1.09 to 1.81)**
 Hyperlipidaemia1.22 (1.11 to 1.34)***0.97 (0.87 to 1.07)0.74 (0.60 to 0.91)**0.72 (0.57 to 0.90)**1.33 (1.10 to 1.62)**1.08 (0.87 to 1.33)
 Chronic kidney disease1.30 (1.16 to 1.46)***0.96 (0.85 to 1.08)1.19 (0.92 to 1.53)1.20 (0.93 to 1.54)1.95 (1.56 to 2.42)***1.34 (1.06 to 1.70)*
 Chronic obstructive pulmonary disease1.31 (1.20 to 1.44)***1.05 (0.95 to 1.16)1.00 (0.82 to 1.23)0.99 (0.80 to 1.22)1.37 (1.13 to 1.66)**0.98 (0.79 to 1.21)
 Peripheral vascular disease1.19 (0.98 to 1.44)0.97 (0.80 to 1.17)0.67 (0.39 to 1.14)0.78 (0.48 to 1.27)1.83 (1.28 to 2.61)***1.03 (0.69 to 1.53)
 Alcohol-related illness0.98 (0.74 to 1.29)1.03 (0.75 to 1.42)2.08 (1.36 to 3.17)***1.89 (1.14 to 3.11)* 1.33 (0.77 to 2.32)1.59 (0.87 to 2.88)
 Mild liver diseases1.18 (0.90 to 1.53)1.06 (0.81 to 1.39)1.62 (1.00 to 2.63)1.09 (0.62 to 1.90)1.60 (0.96 to 2.68)0.95 (0.51 to 1.77)
 Obesity0.62 (0.38 to 1.02)0.75 (0.44 to 1.26)0.89 (0.37 to 2.14)0.89 (0.33 to 2.39)0.78 (0.29 to 2.10)0.75 (0.24 to 2.35)
 Autoimmune disease1.26 (1.15 to 1.38)***0.92 (0.83 to 1.02)0.94 (0.77 to 1.14)0.97 (0.78 to 1.20)1.46 (1.21 to 1.77)***1.07 (0.86 to 1.32)
 Anxiety1.08 (0.98 to 1.20)1.04 (0.92 to 1.16)0.64 (0.50 to 0.82)***0.73 (0.56 to 0.96)* 0.80 (0.64 to 1.01)0.78 (0.60 to 1.01)
 Depression0.99 (0.82 to 1.19)0.96 (0.78 to 1.18)0.85 (0.56 to 1.31)1.40 (0.91 to 2.16)0.78 (0.49 to 1.24)0.93 (0.56 to 1.52)
 Cancer0.92 (0.71 to 1.19)0.72 (0.55 to 0.94)* 1.37 (0.87 to 2.17)1.06 (0.64 to 1.75)1.44 (0.90 to 2.31)1.26 (0.78 to 2.03)
 Trauma1.28 (1.01 to 1.63)* 1.20 (0.96 to 1.51)1.14 (0.67 to 1.95)0.89 (0.50 to 1.59)1.54 (0.93 to 2.53)1.45 (0.91 to 2.32)
 Coronary artery disease1.21 (1.05 to 1.40)**1.02 (0.89 to 1.18)0.87 (0.62 to 1.23)0.82 (0.58 to 1.16)2.10 (1.63 to 2.71)***1.63 (1.26 to 2.11)***
Medication      
 Warfarin1.09 (0.66 to 1.81)1.15 (0.70 to 1.89)2.65 (1.32 to 5.34)**1.74 (0.72 to 4.23)1.28 (0.48 to 3.43)2.41 (1.13 to 5.13)*

  • Crude HR, relative HR.

  • *p<0.05, **p<0.01, ***p<0.001.

  • †Adjusted all variables listing in table 1.