Temporal trends by year in overall survival following hospital discharge between 2004 and 2013 for unadjusted and adjusted flexible parametric survival models (comparing model builds for model including only explanatory variables concluded to have an influence improvements in survival trends (model a) with model containing only variables concluded not to influence improvements in survival trends (model B))
| Six months | One year | |||
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Model A | ||||
| Unadjusted yearly time trend | 0.991 (0.988 to 0.994) | <0.001 | 0.990 (0.987 to 0.993) | <0.001 |
| Yearly time trend adjusted for | ||||
| P2Y12 inhibitors at discharge | 1.041 (1.037 to 1.045) | <0.001 | 1.035 (1.031 to 1.039) | <0.001 |
| P2Y12 inhibitors at discharge and PPCI | 1.066 (1.061 to 1.071) | <0.001 | 1.061 (1.057 to 1.065) | <0.001 |
| Model B | ||||
| Unadjusted yearly time trend | 0.991 (0.988 to 0.994) | <0.001 | 0.990 (0.987 to 0.993) | <0.001 |
| Yearly time trend adjusted for | ||||
| Age, sex and IMD | 0.991 (0.988 to 0.994) | <0.001 | 0.990 (0.987 to 0.993) | <0.001 |
| Age, sex, IMD and pharmacological therapies at discharge (aspirin, statins, β-blockers and ACEi/ARBs) | 0.988 (0.984 to 0.992) | <0.001 | 0.988 (0.985 to 0.991) | <0.001 |
| Age, sex, IMD, pharmacological therapies at discharge (aspirin, statins, β-blockers and ACEi/ARBs) and comorbidities and risk factors | 0.990 (0.987 to 0.994) | <0.001 | 0.990 (0.987 to 0.994) | <0.001 |
| Age, sex, IMD, pharmacological therapies at discharge (aspirin, statins, β-blockers and ACEi/ARBs), comorbidities and risk factors, and cardiac rehabilitation | 0.990 (0.986 to 0.993) | <0.001 | 0.990 (0.986 to 0.993) | <0.001 |
ACEi, ACE inhibitor; ARBs, angiotensin receptor blocker; IMD, Index of Multiple Deprivation; PPCI, primary percutaneous coronary intervention.