Table 2

HRs (95% CI) of mortality according to five comorbidity phenotypes at the time of ischaemic heart disease and by various subgroups

Low burdenCardiometabolicMental healthHigh-burden musculoskeletal vascularHigh-burden musculoskeletal respiratoryTotal
Deaths, n (%)5277 (11)4236 (22)1748 (16)5246 (44)1138 (40)17 645 (19)
Person-years189 16671 53439 95434 9739005344 632
Deaths per 100 person-years2.8 (2.7 to 2.9)5.9 (5.7 to 6.1)4.4 (4.2 to 4.6)15.0 (14.6 to 15.4)12.6 (11.9 to 13.4)5.1 (5.0 to 5.2)
Unadjusted HR mortality (95% CI)1.00 (ref)2.13 (2.04 to 2.21)1.57 (1.48 to 1.65)5.37 (5.17 to 5.58)4.55 (4.27 to 4.86)
Adjusted HR mortality (95% CI)*1.00 (ref)1.46 (1.39 to 1.52)1.55 (1.46 to 1.64)2.38 (2.28 to 2.49)2.62 (2.45 to 2.79)
Subgroup analysisDeaths/nP heterogeneity
Men9 612/57 0881.00 (ref)1.57 (1.48 to 1.67)1.54 (1.40 to 1.68)2.52 (2.37 to 2.68)2.60 (2.38 to 2.84)<0.0001
Women8033/35 0981.00 (ref)1.28 (1.19 to 1.37)1.50 (1.39 to 1.63)2.19 (2.06 to 2.33)2.57 (2.31 to 2.85)
Age <65 years2800/40 4751.00 (ref)1.93 (1.72 to 2.16)1.58 (1.41 to 1.76)3.95 (3.42 to 4.58)3.21 (2.71 to 3.80)<0.0001
Age ≥65 years14 845/51 7111.00 (ref)1.30 (1.24 to 1.36)1.54 (1.44 to 1.65)2.16 (2.06 to 2.26)2.76 (2.57 to 2.96)
Least deprived3241/20 3391.00 (ref)1.56 (1.41 to 1.73)1.64 (1.43 to 1.88)2.45 (2.21 to 2.72)2.86 (2.36 to 3.46)
 23526/19 1961.00 (ref)1.46 (1.34 to 1.61)1.62 (1.42 to 1.86)2.37 (2.17 to 2.60)2.58 (2.18 to 3.04)
 33560/17 9771.00 (ref)1.42 (1.30 to 1.56)1.48 (1.30 to 1.68)2.39 (2.19 to 2.62)2.80 (2.43 to 3.24)0.091
 43387/15 8861.00 (ref)1.35 (1.23 to 1.49)1.44 (1.28 to 1.63)2.28 (2.06 to 2.52)2.52 (2.19 to 2.89)
Most deprived2489/11 3831.00 (ref)1.51 (1.34 to 1.69)1.51 (1.30 to 1.75)2.40 (2.12 to 2.71)2.42 (2.07 to 2.84)
Non-smokers7226/39 2401.00 (ref)1.39 (1.31 to 1.48)1.50 (1.37 to 1.65)2.24 (2.10 to 2.39)2.41 (2.03 to 2.85)
Former smokers6678/31 3261.00 (ref)1.54 (1.43 to 1.64)1.73 (1.58 to 1.89)2.52 (2.35 to 2.70)2.83 (2.58 to 3.10)0.069
Current smokers3493/20 6131.00 (ref)1.50 (1.35 to 1.66)1.41 (1.27 to 1.57)2.40 (2.14 to 2.69)2.46 (2.18 to 2.77)
BMI <25 kg/m26133/24 3901.00 (ref)1.45 (1.35 to 1.56)1.50 (1.36 to 1.65)2.31 (2.14 to 2.49)2.69 (2.42 to 3.00)0.013
BMI ≥25 kg/m29397/58 8401.00 (ref)1.53 (1.45 to 1.62)1.60 (1.48 to 1.73)2.57 (2.42 to 2.73)2.53 (2.30 to 2.79)
Less than 2 years follow-up8475/31 5791.00 (ref)1.52 (1.43 to 1.63)1.42 (1.32 to 1.53)1.98 (1.85 to 2.11)2.22 (2.01 to 2.45)<0.0001
Two or more years follow-up9 170/60 6071.00 (ref)1.43 (1.35 to 1.52)1.47 (1.36 to 1.60)2.33 (2.18 to 2.48)2.53 (2.30 to 2.77)
  • *Adjusted for age, sex, socioeconomic group, BMI and smoking.

  • BMI, body mass index.