Table 1

Baseline characteristics of the five comorbidity phenotypes at the time of diagnosis of ischaemic heart disease

Baseline characteristics of the five comorbidity phenotypes at the time of diagnosis of ischaemic heart disease.
LowCardio-metabolicMental healthHigh-burden musculoskeletal vascularHigh-burden musculoskeletal respiratoryPOverall
n47 41318 87610 98612 049286292 186
Comorbidities, median (IQR)1 (0 to 2)3 (2 to 3)4 (3 to 5)4 (4 to 5)4 (3 to 5)2 (1 to 3)
Comorbidities, mean (SD)1.0 (0.8)2.9 (0.9)3.9 (1.4)4.6 (1.5)4.3 (1.6)<0.0012.3 (1.8)
Age (years)62.6 (12.0)70.6 (10.9)63.7 (12.2)77.5 (10.0)71.0 (9.9)<0.00166.6 (12.7)
BMI (kg/m2), mean (SD)27.5 (4.9)29.1 (5.6)28.6 (6.0)27.7 (5.7)26.7 (5.8)<0.00128.0 (5.4)
Systolic blood pressure (mmHg), mean (SD)137.4 (17.9)141.0 (18.8)136.7 (18.2)136.3 (19.7)136.3 (19.0)<0.001137.9 (18.5)
Women, n (%)13 374 (28.2%)7793 (41.3%)6133 (55.8%)6559 (54.4%)1239 (43.3%)<0.00135 098 (38.1%)
Smoking, n (%)<0.001
 Non-smoker19 384 (40.9%)9282 (49.2%)4143 (37.7%)6059 (50.3%)372 (13.0%)39 240 (42.6%)
 Former14 528 (30.6%)7101 (37.6%)3482 (31.7%)4616 (38.3%)1599 (55.9%)31 326 (34.0%)
 Current12 674 (26.7%)2440 (12.9%)3322 (30.2%)1290 (10.7%)887 (31.0%)20 613 (22.4%)
 Missing827 (1.7%)53 (0.3%)39 (0.4%)84 (0.7%)4 (0.1%)1007 (1.1%)
Socioeconomic group, n (%)<0.001
 Least deprived11 330 (23.9%)4104 (21.7%)1982 (18.0%)2526 (21.0%)397 (13.9%)20 339 (22.1%)
 210 177 (21.5%)3999 (21.2%)2001 (18.2%)2558 (21.2%)461 (16.1%)19 196 (20.8%)
 39127 (19.3%)3754 (19.9%)2173 (19.8%)2334 (19.4%)589 (20.6%)17 977 (19.5%)
 47697 (16.2%)3209 (17.0%)2203 (20.1%)2136 (17.7%)641 (22.4%)15 886 (17.2%)
 Most deprived5302 (11.2%)2145 (11.4%)1869 (17.0%)1535 (12.7%)532 (18.6%)11 383 (12.4%)
 Missing3780 (8.0%)1665 (8.8%)758 (6.9%)960 (8.0%)242 (8.5%)7405 (8.0%)
Medications
 Lipid lowering drugs17 599 (37.1%)11 396 (60.4%)5217 (47.5%)6079 (50.5%)1250 (43.7%)<0.00141 541 (45.1%)
 Antihypertensives24 708 (52.1%)17 381 (92.1%)7730 (70.4%)10 436 (86.6%)2058 (71.9%)<0.00162 313 (67.6%)
 Aspirin15 701 (33.1%)9369 (49.6%)4449 (40.5%)5410 (44.9%)1115 (39.0%)<0.00136 044 (39.1%)
 Oral anticoagulants774 (1.6%)581 (3.1%)295 (2.7%)2299 (19.1%)183 (6.4%)<0.0014132 (4.5%)
 Antiplatelet therapies3385 (7.1%)1619 (8.6%)934 (8.5%)1157 (9.6%)236 (8.3%)<0.0017331 (8.0%)
  • SBP was available for 91 219 individuals, and BMI was available for 83 230 individuals.

  • BMI, body mass index.