Table 3

Receiver operator characteristic curve analysis evaluating biomarkers and structural and functional stress echocardiographic parameters to distinguish between dilated cardiomyopathy and athletic adaptation

VariableOptimal ‘cut-off’*AUCSensitivitySpecificityP value
NT-proBNP>75 pg/mL0.64548.6%96.0%0.045
E′ lateral peak<25 cm/s0.63878.8%48.0%0.066
S′ lateral peak≤21 cm/s0.79284.4%64.0%<0.001
Stroke volume peak≤94 mL0.75462.9%96.0%<0.001
LV ejection fraction≤63%0.90482.9%92.0%<0.0001
Change in LV ejection fraction from baseline to peak exercise≤11%0.90677.1%96.0%<0.0001
  • *Value calculated by Youden’s index as best compromise between sensitivity and specificity.

  • AUC, area under the curve; LV, left ventricular; NT-proBNP, N-terminal pro-brain natriuretic peptide.