Variable | Optimal ‘cut-off’* | AUC | Sensitivity | Specificity | P value |
NT-proBNP | >75 pg/mL | 0.645 | 48.6% | 96.0% | 0.045 |
E′ lateral peak | <25 cm/s | 0.638 | 78.8% | 48.0% | 0.066 |
S′ lateral peak | ≤21 cm/s | 0.792 | 84.4% | 64.0% | <0.001 |
Stroke volume peak | ≤94 mL | 0.754 | 62.9% | 96.0% | <0.001 |
LV ejection fraction | ≤63% | 0.904 | 82.9% | 92.0% | <0.0001 |
Change in LV ejection fraction from baseline to peak exercise | ≤11% | 0.906 | 77.1% | 96.0% | <0.0001 |
*Value calculated by Youden’s index as best compromise between sensitivity and specificity.
AUC, area under the curve; LV, left ventricular; NT-proBNP, N-terminal pro-brain natriuretic peptide.