Postexercise troponin rise in HCM: multivariable logistic regression
| Variables with an independent association: | Adjusted OR (95% CI) | P value |
| (a) Model-1—clinical variables* | ||
| Heart rate at maximum exercise | 1.4 (1.1 to 1.7)† | 0.007 |
| (b) Model-2—clinical & biomarker information* | ||
| Heart rate at maximum exercise | 1.4 (1.1 to 1.7)† | 0.007 |
| (c) Model-3—clinical, biomarker & CMR information‡ | ||
| HighT2 | 7.9 (2.7 to 23.3) | <0.001 |
(a) Model-1: evaluated variables are: resting heart rate; heart rate at maximum exercise; heart rate pressure product; (b) Model-2: evaluated variables are: model-1+pre-exercise cardiac troponin T level ≥14 ng/L; (c) Model-3: evaluated variables are: model-2+maximal wall thickness; presence of late gadolinium enhancement; presence of elevated signal intensity on T2-weighted imaging.
*Performance of model-1 and model-2: C-statistic (95% CI) 0.69 (0.59–0.80).
†OR per 10 beats/min increase.
‡Performance of model-3: C-statistic (95% CI) 0.73 (0.60–0.86).
CMR, cardiac magnetic resonance; HighT2, elevated signal intensity on T2-weighted imaging.