Table 4

Postexercise troponin rise in HCM: multivariable logistic regression

Variables with an independent association:Adjusted OR (95% CI)P value
(a) Model-1—clinical variables*
 Heart rate at maximum exercise1.4 (1.1 to 1.7)†0.007
(b) Model-2—clinical & biomarker information*
 Heart rate at maximum exercise1.4 (1.1 to 1.7)†0.007
(c) Model-3—clinical, biomarker & CMR information‡
 HighT27.9 (2.7 to 23.3)<0.001
  • (a) Model-1: evaluated variables are: resting heart rate; heart rate at maximum exercise; heart rate pressure product; (b) Model-2: evaluated variables are: model-1+pre-exercise cardiac troponin T level ≥14 ng/L; (c) Model-3: evaluated variables are: model-2+maximal wall thickness; presence of late gadolinium enhancement; presence of elevated signal intensity on T2-weighted imaging.

  • *Performance of model-1 and model-2: C-statistic (95% CI) 0.69 (0.59–0.80).

  • †OR per 10 beats/min increase.

  • ‡Performance of model-3: C-statistic (95% CI) 0.73 (0.60–0.86).

  • CMR, cardiac magnetic resonance; HighT2, elevated signal intensity on T2-weighted imaging.