Table 2

Laboratory values

Overallhs-TnI −/BNP −hs-TnI −/BNP +hs-TnI +/BNP −hs-TnI +/BNP +P value
No. of patients 397 208 59 40 90
hs-TnI, ng/L
 Baseline7.8 (4.5–25.6)5.1 (2.95–6.95)9.3 (5.1–13.4)34.7 (25.9–55.3)50.3 (32.2–161.7)<0.001
 Max during hospitalisation10.8 (4.3–39.5)4.85 (2.95–9.3)11.6 (7–22.8)39.6 (33.3–92.6)79.1 (38.6–238.1)<0.001
BNP, pg/mL
 Baseline53 (27–147)30 (18.5–50)170.5 (135–224)46.5 (24–70.5)261.5 (184.5–500.5)<0.001
 Max during hospitalisation67 (30–191)37 (20–62.5)203 (136–306)54 (29.5–84.5)304 (201.5–593)<0.001
D-Dimer, ng/mL
 Baseline470 (296–882)360 (264–575)622 (332–1059)444 (300–823)795 (408–1711)<0.001
 Max during hospitalisation844 (412–2462)621 (322–1090)1080 (559–2826)1807 (480–4656)1330 (661–3640)<0.001
Fibrinogen, mg/dL
 Baseline552 (441–665)550 (450–646)487 (384–636)560 (418–646)587 (455–725)0.013
 Max during hospitalisation617 (487–728)607 (490.5–725)583 (459–728)590.5 (503–725)639 (512–778)0.075
CRP, mg/dL
 Baseline8.04 (3.08–15.28)6.82 (2.33–12.38)9.65 (2.79–16.15)7.955 (4.585–19.06)10.685 (6.02–18.86)0.307
 Max during hospitalisation15.46 (8.75–24.13)13.13 (5.7–20.29)19.45 (10.64–27.88)20.635 (10.47–29.23)19.775 (11.66–28.13)<0.001
IL-6, pg/mL
 Baseline44 (18–87)45 (19–87)52 (21–100)26 (12–73)40 (18–94)0.704
 Max during hospitalisation57 (23–145)52 (23–114)98 (31–194)57 (13–185)53 (22–123)0.430
Ferritine, ng/mL
 Baseline536.2 (226.1–1004.1)479.85 (216.3–966.8)457.2 (255.9–1005.6)323.9 (218.7–902.7)757.1 (375.9–1370.1)0.084
 Max during hospitalisation725.7 (284.4–1290.9)679.65 (282.6–1224.1)667.4 (272.6–1274.6)513.6 (229.2–1014.2)871.45 (545–1613)0.354
Creatinine, mg/dL
 Baseline0.95 (0.75–1.21)0.85 (0.71–1.04)1.01 (0.73–1.38)1.13 (0.89–1.45)1.17 (0.82–1.81)<0.001
 Max during hospitalisation1 (0.79–1.37)0.91 (0.74–1.09)1.04 (0.81–1.54)1.24 (0.89–1.73)1.46 (0.98–2.17)<0.001
White cell count, 103/mm3
 Baseline6.46 (5.12–9.82)5.965 (5.095–8.56)7.98 (5.95–11.45)6.865 (5.315–11.07)6.67 (4.85–10.27)0.007
 Max during hospitalisation8.91 (6.65–12.6)7.86 (5.98–10.62)10.85 (8.01–15.05)10.62 (7.19–14.485)10.855 (6.96–14.06)0.003
Neutrophils, 103/mm3
 Baseline4.9 (3.5–7.7)4.5 (3.4–6.7)5.9 (4.1–8.8)5.65 (3.55–9.15)5.25 (3.2–9)0.333
 Max during hospitalisation6.7 (4.7–10.4)5.8 (4.2–8.8)8.5 (6.1–12.8)8.95 (5.15–12.25)9 (5.5–12.4)<0.001
Lymphocytes, 103/mm3
 Baseline1 (0.6–1.3)1 (0.7–1.35)1 (0.6–1.4)0.95 (0.6–1.2)0.85 (0.5–1.2)0.333
 Min during hospitalisation0.7 (0.4–1)0.8 (0.5–1.2)0.6 (0.4–0.9)0.6 (0.4–0.85)0.4 (0.3–0.7)0.135
Platelets baseline, 103/mm3 201 (154–254)204.5 (162–254.5)210 (161–279)193.5 (154.5–233.5)188.5 (131–257)0.322
Haemoglobin baseline, g/dL14 (12.7–15)14.3 (13.35–15.4)13.6 (12.1–14.6)14.25 (13.1–15.2)12.8 (11.8–14.1)
Procalcitonin, ng/mL
 Baseline0.18 (0.09–0.44)0.135 (0.08–0.25)0.285 (0.145–0.51)0.36 (0.11–0.73)0.36 (0.13–1.43)0.026
 Max during hospitalisation0.36 (0.16–1.23)0.2 (0.11–0.47)0.515 (0.24–1.88)0.77 (0.29–1.61)0.73 (0.36–3.16)0.001
ALT baseline, IU/L27 (18–44)28.5 (19–45)24 (16–41)34 (25–53.5)25.5 (16–37)0.113
ALP baseline, U/L77 (61–103)72 (59–92)81 (61–110)79 (64–102)91 (65–128)0.035
Total bilirubin baseline, mg/dL0.6 (0.5–0.8)0.6 (0.5–0.8)0.6 (0.5–1.1)0.6 (0.5–0.8)0.7 (0.5–0.9)0.496
PT ratio baseline1.1 (1.05–1.21)1.1 (1.04–1.22)1.11 (1.03–1.19)1.1 (1.045–1.185)1.11 (1.06–1.22)0.719
PTT ratio baseline0.98 (0.9–1.06)0.97 (0.9–1.04)0.98 (0.9–1.05)0.945 (0.89–1.025)1 (0.93–1.09)0.670
INR baseline1.1 (1.05 - 1–2)1.1 (1.04–1.21)1.11 (1.03–1.19)1.095 (1.045–1.185)1.11 (1.06–1.21)0.718
  • Availability of baseline laboratory values, indicated as n/N (%) when <100%: hs-TnI: 380/397 (96%); BNP: 366/397 (92%); D-dimer: 350/397 (88%); fibrinogen: 382/397 (96%); IL-6: 273/397 (69%); ferritine: 367/397 (92%); procalcitonin: 337/397 (92%); ALP: 329/397 (90%).

  • ALP, alkaline phosphatase; ALT, alanine aminotransferase; BNP, B-type natriuretic peptide; CRP, C reactive protein; hs-TnI, high-sensitivity troponin I; IL, interleukin; INR, international normalized ratio; INR, international normalised ratio; PT, prothrombin time; PTT, partial thromboplastin time.