Table 3

Cox proportional regression models for aortic stenosis progression

HR (95% CI)P valueOverall p value
Crude model
 Non-user (reference)10.268
 Unfavourable DPP-4 inhibitor1.054 (0.61 to 1.83)0.853
 Favourable DPP-4 inhibitor0.318 (0.08 to 1.33)0.117
Model 1 (adjusted for baseline AS severity)
 Non-user (reference)10.041
 Unfavourable DPP-4 inhibitor0.837 (0.61 to 1.83)0.536
 Favourable DPP-4 inhibitor0.148 (0.03 to 0.66)0.012
Model 2 (adjusted for baseline AS severity and age)
 Non-user (reference)10.038
 Unfavourable DPP-4 inhibitor0.870 (0.49 to 1.54)0.631
 Favourable DPP-4 inhibitor0.141 (0.03 to 0.64)0.011
Model 3 (adjusted for baseline AS severity, age and renal function)
 Non-user (reference)10.025
 Unfavourable DPP-4 inhibitor0.858 (0.49 to 1.52)0.597
 Favourable DPP-4 inhibitor0.116 (0.02 to 0.55)0.007
  • AS, aortic stenosis; DPP-4, dipeptidyl peptidase-4.