Table 4

Treatment effects on secondary outcomes.

VariablenEnhanced self-management
(control)
nSupported medical management
(intervention)
P for change
End mean (SD)Change mean (SD)End mean (SD)Change mean (SD)
NYHA score962.22 (0.94)0.09 (0.41)882.17 (0.92)0.01 (0.41)0.17
MAGGIC score8822.55 (7.59)−0.10 (1.53)9422.22 (6.87)0.0 (1.32)0.63
BNP (pg/mL)*57140.2 (55.7 to 295.2)−1.10 (72.5)4325.6 (95.0 to 416.0)−7.94 (38.1)0.57
NT-pro-BNP (pg/mL)*32853.5 (393.5 to 2361.2)52.37 (331.6)41120.0 (311.5 to 1481.5)−372.5 (2371.2)0.26
Blood pressure systolic (mm Hg)96122.4 (20.6)1.26 (13.4)91122.2 (19.4)−2.88 (12.8)0.03
Blood pressure diastolic (mm Hg)9671.5 (10.5)−0.37 (7.3)9170.8 (10.0)−1.33 (7.2)0.37
Binary outcomesBaseline n/N (%)Final n/N (%)Baseline n/N (%)Final n/N (%)Pfinal
Heart rate 50 to 70 bpm (if in sinus rhythm)45/90 (50)27/63 (42.8)49/95 (51.6)39/61 (53.9)0.02
Serum potassium (4.0 to 4.9 mmol/L)64/101 (63.4)58/88 (65.9)65/101 (64.4)55/83 (66.3)0.96
Controlled hypertension (SBP <130 and DBP <80 mm Hg)56/101 (55.4)61/97 (62.8)54/101 (53.5)60/98 (61.2)0.81
Diagnosis of depression4/79 (5.1)13/76 (17.1)7/79 (8.9)16/78 (20.5)0.58
  • *For quantitative variables that are known to be skewed, median (first, third quartile) shown instead.

  • bpm, beats per minute; DBP, diastolic blood pressure; n, sample size; SBP, systolic blood pressure.