Table 4

Parameter estimates and P values from the mixed effects models describing the relationship between newly diagnosed diabetes and health status outcomes

Health status outcomes	Reference group	Estimate (Unadjusted models)	95% CI	P value	Estimate (Adjusted models*)	95% CI	P value
SAQ-Angina Frequency
Newly diagnosed diabetes	Established diabetes	3.79	2.29 to 5.31	<0.0001	5.05	2.50 to 7.59	0.0001
Newly diagnosed diabetes*time2 interaction							0.0009
Newly diagnosed diabetes*time3 interaction							0.0235
Newly diagnosed diabetes	Without diabetes	0.07	−1.17 to 1.30	0.9158	0.24	−0.95 to 1.43	0.6928
Newly diagnosed diabetes*time2 interaction							0.8398
Newly diagnosed diabetes*time3 interaction							0.5656
SAQ-Physical Limitations
Newly diagnosed diabetes	Established diabetes	4.11	2.38 to 5.84	<0.0001	6.71	3.67 to 9.74	<0.0001
Newly diagnosed diabetes*time2 interaction							<0.0001
Newly diagnosed diabetes*time3 interaction							0.0011
Newly diagnosed diabetes	Without diabetes	0.57	−0.89 to 2.04	0.4450	−1.55	−3.7 to 0.60	0.1575
Newly diagnosed diabetes*time2 interaction							0.0311
Newly diagnosed diabetes*time3 interaction							0.0183
SAQ-Quality of Life
Newly diagnosed diabetes	Established diabetes	6.19	4.08 to 8.29	<0.0001	4.35	1.37 to 7.34	0.0041
Newly diagnosed diabetes*time2 interaction							0.1143
Newly diagnosed diabetes*time3 interaction							0.2473
Newly diagnosed diabetes	Without diabetes	3.08	1.28 to 4.88	0.001	2.58	0.97 to 4.20	0.0018
Newly diagnosed diabetes*time2 interaction							0.5455
Newly diagnosed diabetes*time3 interaction							0.5489
SF-12 Mental Functioning
Newly diagnosed diabetes	Established diabetes	2.82	1.83 to 3.81	<0.0001	0.33	−0.88 to 1.56	0.5913
Newly diagnosed diabetes*time2 interaction							0.6385
Newly diagnosed diabetes*time3 interaction							0.9505
Newly diagnosed diabetes	Without diabetes	0.96	0.07 to 1.85	0.0354	−0.36	−1.35 to 0.62	0.4646
Newly diagnosed diabetes*time2 interaction							0.0005
Newly diagnosed diabetes*time3 interaction							0.1049
SF-12 Physical Functioning
Newly diagnosed diabetes	Established diabetes	4.31	3.19 to 5.43	<0.0001	0.77	−0.40 to 1.94	0.1959
Newly diagnosed diabetes*time2 interaction							0.2478
Newly diagnosed diabetes*time3 interaction							0.7762
Newly diagnosed diabetes	Without diabetes	−1.43	−2.38 to −0.48	0.0034	−0.60	−1.43 to 0.22	0.1535
Newly diagnosed diabetes*time2 interaction							0.8236
Newly diagnosed diabetes*time3 interaction							0.6423
EQ-5D Visual Analogue Scale
Newly diagnosed diabetes	Established diabetes	6.93	5.06 to 8.80	<0.0001	4.26	1.70 to 6.82	0.005
Newly diagnosed diabetes*time2 interaction							0.0036
Newly diagnosed diabetes*time3 interaction							0.3973
Newly diagnosed diabetes	Without diabetes	0.92	−0.64 to 2.49	0.2481	1.19	−0.25 to 2.63	0.106
Newly diagnosed diabetes*time2 interaction							0.7887
Newly diagnosed diabetes*time3 interaction							0.2543

P value numbers in bold denote statistical significance at the p<0.05 level.
*Models adjusted for cardiometabolic characteristics, gender, sociodemographics, CVD risk factors, other comorbidities, AMI treatment, clinical characteristics of AMI, non-pharmacological interventions, psychosocial and behavioural factors, self-reported socioeconomic status and time.
CVD, cardiovascular disease; EQ-5D-VAS, Euro-Quality of Visual Analogue Scale; NS, not significant; SAQ, Seattle Angina Questionnaire; SF-12, 12 Item Short Form Survey; Time2, indicator of the 1-month follow-up time point; Time3, indicator of the 12-month follow-up time point.