Table 2

Comparisons of the echocardiographic variables between Tb and T1

	Tb	T1	P value
Heart rate, bpm	74±13	77±14	0.078
Systolic blood pressure, mm Hg	120±20	119±17	0.46
LVEDV, mL	89±26	90±23	0.65
LVESV, mL	31±11	33±9	0.11
LVEF, %	65±4	63±4	0.003
LAVi, mL/m²	28±9	30±10	0.25
E, cm/s	74±21	68±18	0.007
A, cm/s	74±23	75±22	0.81
E/A ratio	1.1±0.5	1.0±0.4	0.012
e', cm/s	10.9±2.9	11.0±2.6	0.22
a', cm/s	11.0±2.6	11.0±2.8	0.36
E/e' ratio	7.1±2.8	7.0±3.2	0.82
TRV, m/s	2.2±0.4	2.2±0.3	0.35
TAPSE, mm	22±3	21±3	0.49
GLS, %	23.2±2.6	22.2±2.4	<0.001

Values are mean±SD. p<0.05, Tb versus T1. Tb was determined as the timing of echocardiographic study just before anthracycline administration, and T1 as the timing of the first echocardiographic study after starting of anthracycline administration.
a’, peak atrial systolic mitral annular velocity; A, peak atrial diastolic wave velocity; e’, peak early diastolic mitral annular velocity; E, peak early diastolic wave velocity; GLS, global longitudinal strain; LAVi, left atrial volume index; LVEDV, left ventricular end diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end systolic volume; TAPSE, tricuspid annular plane systolic excursion; TRV, tricuspid regurgitation velocity.