Table 3

Major adverse cardiac events in women with aortic coarctation

NoDiagnosisComorbiditiesPrepregnancy cardiac functionGA at eventMedication and interventionsTiming and mode of delivery
1HFVSD; pulmonary hypertension; aortic stenosisNYHA 3
LVEF >40%
Signs of HF: no
16Sildenafil, bosentan, LMWH34+2
CS
2HFVSD; mitral stenosisNYHA 1
LVEF <40%
Signs of HF: no
23Metoprolol, furosemide34+4
CS
3HFVSD; pulmonary valve stenosis, aortic regurgitationNYHA 2
LVEF <40%
Signs of HF: no
33Metoprolol, spironolacton35+1
CS
4HFPDA; BAV; aortic regurgitationNYHA 1
LVEF >40% signs HF: yes
33Unknown36+2
eCS
5HFVSD; aortic stenosis and regurgitation; HTNYHA 2
LVEF >40%
Signs of HF: no
28Unknown35
CS
6HFPDANYHA 2
LVEF >40% signs HF: yes
13Metoprolol38+4
CS
7HFNoneNYHA 2
LVEF >40% signs HF: yes
28Unknown; diagnostic aortography37+1
eCS
8HFUnrepaired CoA; HTNYHA 1
LVEF >40%
Signs of HF: no
38Unknown39+5
CS
9HFASD; mitral regurgitation; HTNYHA 2
LVEF >40%
Signs of HF: no
26Calcium channel blocker, methyldopa38+5
Vaginal
10HFMitral regurgitation; HTNYHA 2
LVEF >40% signs HF: yes
16Unknown38
Vaginal
11AFBAV; mitral regurgitationNYHA unknown
LVEF >40%
Signs of HF: no
UnknownMetoprololUnknown
Vaginal
12AFBAV; aortic stenosis and regurgitation; mitral stenosis and regurgitation; pulmonary valve regurgitationNYHA 1
LVEF >40%
Signs of HF: no
16Metoprolol, acetylsalicylic acid39+6
Vaginal
13AFBAV; aortic and mitral stenosisNYHA 1
LVEF >40%
Signs of HF: no
2940+6
Vaginal
  • AF, atrial fibrillation; BAV, bicuspid aortic valve; CoA, aortic coarctation; (e)CS, (emergency) caesarean section; GA, gestational age (weeks+days if available); HF, heart failure; HT, hypertension; LMWH, low molecular weight heparin; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association.