Comparison | MACE | CVD | HF | SVA | MI |
Men with classical FD versus men with non-classical FD | 6.1 (2.4–17.0)* | 22.2 (5.0–19.3)* | 15.5 (3.7–82.7)* | 5.1 (0.9–41.1) | 3.1 (1.0–11.7) |
Men with classical FD versus women with classical FD | 5.0 (2.3–11.0)* | 14.8 (4.3–67.0)* | 15.4 (4.1–73.8)* | 10.7 (1.9–92.0)* | 2.5 (1.0–6.7) |
Men with non-classical FD versus women with classical FD | 0.8 (0.3–2.0) | 0.7 (0.1–2.7) | 1 (0.3–3.4) | 2.1 (0.4–13.0) | 0.8 (0.2–2.4) |
These HRs where obtained from Firth’s penalised COX regression models in which sex and phenotype where combined in one variable with four patient groups.
*P<0.008.
CVD, cardiovascular death; FD, Fabry disease; HF, heart failure; MACE, major adverse cardiovascular event; MI, myocardial infarction; SVA, sustained ventricular arrhythmia.