Table 4

Scenario analyses: cost-effectiveness results

Mean cost per patientMean QALY per patientICERMean cost per patientMean QALY per patientICER
Not controlling for differential revascularisation ratesNHS tariffs
Low PTLNICE£739.722.20158Low PTLNICE£727.672.20095
CMR£890.252.27686£1999.70MPS£791.102.22261Dominated
MPS£1066.302.22813DominatedCMR£875.512.28702£1310.57
Medium PTLCMR£1314.132.21530Medium PTLMPS£1135.142.17327
MPS£1322.852.23666DominatedNICE£1309.261.99474Dominated
NICE£1619.412.05109DominatedCMR£1311.502.19738£7317.38
High PTLNICE£2484.192.17658High PTLMPS£2347.231.97525
MPS£2504.962.14166DominatedCMR£2532.142.15591£1023.51
CMR£2728.522.19613£12 495.02NICE£2604.592.04944Dominated
OverallMPS£1686.592.19981OverallMPS£1486.942.11400
NICE£1704.732.13613DominatedNICE£1629.342.06854Dominated
CMR£1718.792.22440£1309.99CMR£1642.402.20568£1695.61
Diagnostic costs onlyRevised MPS unit costs
Low PTLNICE£430.212.20095Low PTLNICE£775.502.20095
CMR£458.952.28702£333.92MPS£806.952.22261Extendedly dominated
MPS£695.642.22261DominatedCMR£844.722.28702£586.35
Medium PTLCMR£581.882.19738Medium PTLMPS£1143.372.17327
MPS£768.272.17327DominatedCMR£1308.542.19738£6853.24
NICE£821.611.99474DominatedNICE£1313.721.99474Dominated
High PTLCMR£827.452.15591High PTLMPS£2398.761.97525
MPS£988.421.97525DominatedCMR£2511.512.15591£768.46
NICE£1 1123.812.04944DominatedNICE£2621.232.04944Dominated
OverallCMR£639.252.20568OverallMPS£1512.942.11400
NICE£829.482.06854DominatedCMR£1625.732.20568£1230.20
MPS£829.522.11400DominatedNICE£1649.572.06854Dominated
EQ-5D-5LPFIA
Low PTLNICE£787.922.43234Low PTLNICE£794.342.15534
CMR£846.002.47754£1285.02PFIA£963.272.25924£1625.92
MPS£1061.942.45839Dominated
Medium PTLCMR£1301.972.41772Medium PTLPFIA£1344.222.20270
MPS£1391.202.40701DominatedNICE£1563.732.02996Dominated
NICE£1565.282.30330Dominated
High PTLCMR£2514.862.36506High PTLPFIA£2579.612.13792
NICE£2638.372.26125DominatedNICE£2617.762.14353£6800.50
MPS£2660.932.31846Dominated
OverallCMR£1624.822.41415OverallPFIA£1695.812.19386
NICE£1753.242.32169DominatedNICE£1747.782.10410Dominated
MPS£1767.872.38816Dominated
  • The full results for each scenario are reported in online supplementary tables S7–S12.

  • CMR, cardiovascular magnetic resonance; ICER, incremental cost-effectiveness ratio; MPS, myocardial perfusion scintigraphy; NHS, National Health Service; NICE, National Institute for Health and Care Excellence guidance; PFIA, pooled functional imaging arm; PTL, pretest likelihood; QALY, quality-adjusted life-years.