Table 3

Association between repeated hs-CRP levels and endpoints, adjusted for clinical characteristics and (repeated) NT-proBNP and hs-TnT

	Death or HF (n=69)		Any MACE (n=228)
	HR (95% CI)	P value	HR (95% CI)	P value
Repeated hs-CRP, mg/L (unadjusted)	2.14 (1.73 to 2.73)	<0.001	1.22 (1.10 to 1.37)	<0.001
Adjusted for baseline characteristics*	1.77 (1.38 to 2.31)	<0.001	1.08 (0.96 to 1.22)	0.230
Adjusted for baseline NT-proBNP	1.68 (1.35 to 2.10)	<0.001	1.05 (0.94 to 1.18)	0.397
Adjusted for baseline characteristics and baseline NT-proBNP	1.60 (1.26 to 2.05)	<0.001	1.03 (0.92 to 1.16)	0.585
Repeated hs-CRP and NT-proBNP
Repeated hs-CRP, mg/L	1.53 (1.20 to 2.00)	0.002	0.99 (0.88 to 1.12)	0.916
Repeated NT-proBNP, pmol/L	2.48 (2.04 to 2.98)	<0.001	1.62 (1.48 to 1.76)	<0.001
Repeated hs-CRP and hs-TnT
Repeated hs-CRP, mg/L	1.94 (1.52 to 2.50)	<0.001	1.13 (1.00 to 1.27)	0.044
Repeated hs-TnT, ng/mL	2.46 (1.93 to 3.15)	<0.001	1.57 (1.38 to 1.78)	<0.001
Repeated hs-CRP, hs-TnT and NT-proBNP
Repeated hs-CRP, mg/L	1.54 (1.24 to 1.98)	<0.001	1.00 (0.89 to 1.12)	0.984
Repeated hs-TnT, ng/mL	1.19 (0.85 to 1.57)	0.248	1.11 (0.96 to 1.28)	0.146
Repeated NT-proBNP, pmol/L	2.20 (1.74 to 2.86)	<0.001	1.53 (1.39 to 1.69)	<0.001

HRs are expressed per twofold higher biomarker level.
*Age, sex, congenital diagnosis, NYHA, cardiac medication, systemic ventricular function.
HF, heart failure; hs-CRP, high-sensitivity C reactive protein; hs-TnT, high-sensitivity troponin T; MACE, major adverse cardiac event; NT-proBNP, N-terminal pro B type natriuretic peptide.