Death or HF (n=69) | Any MACE (n=228) | |||
HR (95% CI) | P value | HR (95% CI) | P value | |
Repeated hs-CRP, mg/L (unadjusted) | 2.14 (1.73 to 2.73) | <0.001 | 1.22 (1.10 to 1.37) | <0.001 |
Adjusted for baseline characteristics* | 1.77 (1.38 to 2.31) | <0.001 | 1.08 (0.96 to 1.22) | 0.230 |
Adjusted for baseline NT-proBNP | 1.68 (1.35 to 2.10) | <0.001 | 1.05 (0.94 to 1.18) | 0.397 |
Adjusted for baseline characteristics and baseline NT-proBNP | 1.60 (1.26 to 2.05) | <0.001 | 1.03 (0.92 to 1.16) | 0.585 |
Repeated hs-CRP and NT-proBNP | ||||
Repeated hs-CRP, mg/L | 1.53 (1.20 to 2.00) | 0.002 | 0.99 (0.88 to 1.12) | 0.916 |
Repeated NT-proBNP, pmol/L | 2.48 (2.04 to 2.98) | <0.001 | 1.62 (1.48 to 1.76) | <0.001 |
Repeated hs-CRP and hs-TnT | ||||
Repeated hs-CRP, mg/L | 1.94 (1.52 to 2.50) | <0.001 | 1.13 (1.00 to 1.27) | 0.044 |
Repeated hs-TnT, ng/mL | 2.46 (1.93 to 3.15) | <0.001 | 1.57 (1.38 to 1.78) | <0.001 |
Repeated hs-CRP, hs-TnT and NT-proBNP | ||||
Repeated hs-CRP, mg/L | 1.54 (1.24 to 1.98) | <0.001 | 1.00 (0.89 to 1.12) | 0.984 |
Repeated hs-TnT, ng/mL | 1.19 (0.85 to 1.57) | 0.248 | 1.11 (0.96 to 1.28) | 0.146 |
Repeated NT-proBNP, pmol/L | 2.20 (1.74 to 2.86) | <0.001 | 1.53 (1.39 to 1.69) | <0.001 |
HRs are expressed per twofold higher biomarker level.
*Age, sex, congenital diagnosis, NYHA, cardiac medication, systemic ventricular function.
HF, heart failure; hs-CRP, high-sensitivity C reactive protein; hs-TnT, high-sensitivity troponin T; MACE, major adverse cardiac event; NT-proBNP, N-terminal pro B type natriuretic peptide.