Potential mechanisms of cardiovascular benefits associated with SGLT2-inhibitor therapy
| Conventional mechanisms | Novel mechanisms |
| Diuresis and reduction in blood pressure | Improved myocardial energetics |
| Improved glycaemic control | Improved myocardial ionic homeostasis |
| Weight loss | Autophagy |
| Increase in red blood cell mass and haematocrit | Altered adipokine regulation |