Association between women with recreational substance use and premature ASCVD
| Recreational substances | Women with premature ASCVD (n=18 964) n (%) | Women with non-premature ASCVD (n=8137) n (%) | P value | *Adjusted OR (95% CI) |
| Tobacco use | 10 144 (53.5%) | 2510 (30.9%) | <0.01 | 2.40 (2.26 to 2.55) |
| Alcohol use | 3609 (19.0%) | 448 (5.5%) | <0.01 | 2.13 (1.91 to 2.39) |
| Illicit drug use | 2428 (12.8%) | 96 (1.2%) | <0.01 | 5.64 (4.55 to 7.00) |
| Cocaine use | 1305 (6.9%) | 35 (0.4%) | <0.01 | 5.08 (3.58 to 7.19) |
| Amphetamine use | 341 (1.8%) | 11 (0.1%) | <0.01 | 4.97 (2.69 to 9.20) |
| Cannabis use | 1456 (7.7%) | 51 (0.6%) | <0.01 | 5.52 (4.13 to 7.37) |
| Other drugs/unspecified | 439 (38.5%) | 63 (0.8%) | <0.01 | 4.25 (3.25 to 5.54) |
*Adjusted for patient’s race, obesity, hypertension, diabetes mellitus, hypercholesterolaemia, presence of ischaemic heart disease and Diagnostic Cost Group Relative Risk Score (marker of patient’s overall illness burden). In addition, this model was adjusted for two other categories of drug use (eg, tobacco use regression model was adjusted for concomitant alcohol abuse and illicit drug use).
ASCVD, atherosclerotic cardiovascular disease.