Variables | Primary outcomes | Secondary outcomes | ||||||||||
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||
HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | |
Male | 1.19 | 0.66 to 2.14 | 0.573 | 0.54 | 0.26 to 1.14 | 0.105 | 1.33 | 0.68 to 2.63 | 0.409 | 0.54 | 0.23 to 1.28 | 0.163 |
Age | 1.01 | 0.99 to 1.02 | 0.556 | 0.99 | 0.97 to 1.01 | 0.206 | 1.00 | 0.98 to 1.02 | 0.958 | 0.98 | 0.96 to 1.00 | 0.046 |
Previous systemic thromboembolism | 2.48 | 1.38 to 4.49 | 0.003 | 1.15 | 0.55 to 2.41 | 0.721 | 3.01 | 1.60 to 5.64 | 0.001 | 1.56 | 0.70 to 3.49 | 0.283 |
SCD family history | 3.13 | 1.48 to 6.63 | 0.003 | 1.77 | 0.72 to 4.37 | 0.217 | 3.39 | 1.51 to 7.61 | 0.003 | 1.84 | 0.67 to 5.02 | 0.235 |
NYHA functional class III/IV | 4.11 | 2.12 to 7.94 | <0.001 | 1.16 | 0.52 to 2.59 | 0.723 | 5.37 | 2.40 to 12.02 | <0.001 | 1.45 | 0.53 to 4.00 | 0.474 |
Ln Big ET-1* | 2.67 | 2.04 to 3.49 | <0.001 | 1.83 | 1.27 to 2.62 | 0.001 | 3.08 | 2.31 to 4.11 | <0.001 | 1.93 | 1.32 to 2.83 | 0.001 |
Ln NT-pro-BNP | 2.03 | 1.59 to 2.60 | <0.001 | 1.65 | 1.22 to 2.24 | 0.001 | 2.33 | 1.74 to 3.12 | <0.001 | 1.94 | 1.35 to 2.79 | <0.001 |
Ln LVEF | 0.21 | 0.12 to 0.38 | <0.001 | 0.72 | 0.30 to 1.75 | 0.472 | 0.18 | 0.09 to 0.36 | <0.001 | 0.91 | 0.33 to 2.50 | 0.859 |
Ln LVEDV | 4.09 | 2.12 to 7.91 | <0.001 | 0.39 | 0.07 to 2.16 | 0.278 | 6.18 | 2.92 to 13.06 | <0.001 | 0.55 | 0.06 to 4.67 | 0.580 |
LVEDD | 1.07 | 1.04 to 1.10 | <0.001 | 1.05 | 0.98 to 1.11 | 0.152 | 1.08 | 1.05 to 1.11 | <0.001 | 1.04 | 0.97 to 1.12 | 0.278 |
LGE | 6.96 | 2.52 to 19.28 | <0.001 | 5.43 | 1.74 to 16.91 | 0.003 | 11.46 | 2.77 to 47.35 | 0.001 | 8.20 | 1.76 to 38.09 | 0.007 |
Bold and italic values are statistically significant (p<0.05).
*Big ET-1 levels were regarded as a continuous variable.
Big ET-1, big endothelin-1; LGE, late gadolinium enhancement; LVEDD, left ventricular end-diastolic diameter; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricle ejection fraction; LVEF, left ventricle ejection fraction; NT-pro-BNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association; SCD, sudden cardiac death.