Association between lipoprotein(a) and presence of aortic valve calcium: separate cohorts
| Rotterdam Study cohort Presence of AVC | ||||
| Model 1 | Model 2 | Model 3 | Model 4 | |
| Lp(a), per 50 mg/dL increase | 1.44 (1.28 to 1.61) | 1.56 (1.38 to 1.76) | 1.54 (1.36 to 1.75) | 1.53 (1.34 to 1.73) |
| Lp(a) categories | ||||
| <50th percentile (<12.5 mg/dL) | 1.00 | 1.00 | 1.00 | 1.00 |
| 50th–79th percentile (12.5–51.4 mg/dL) | 1.04 (0.85 to 1.27) | 1.02 (0.83 to 1.26) | 0.99 (0.80 to 1.23) | 0.96 (0.77 to 1.19) |
| 80th–94th percentile (51.4–96.6 mg/dL) | 1.78 (1.40 to 2.27) | 1.85 (1.43 to 2.40) | 1.85 (1.42 to 2.40) | 1.81 (1.39 to 2.36) |
| ≥95th percentile (>96.6 mg/dL) | 2.39 (1.64 to 3.49) | 3.04 (2.02 to 4.58) | 2.92 (1.93 to 4.42) | 2.93 (1.91 to 4.50) |
| Amsterdam UMC cohort Presence of AVC | ||||
| Lp(a), per 50 mg/dL increase | 2.17 (1.31 to 3.60) | 2.12 (1.25 to 3.58) | 2.02 (1.19 to 3.44) | 2.09 (1.23 to 3.55) |
| Lp(a) categories | ||||
| <50th percentile (<12.6 mg/dL) | 1.00 | 1.00 | 1.00 | 1.00 |
| 50th–79th percentile (12.6–42.4 mg/dL) | 1.46 (0.69 to 3.13) | 1.21 (0.55 to 2.65) | 1.21 (0.55 to 2.65) | 1.12 (0.50 to 2.49) |
| 80th–94th percentile (42.4–74.3 mg/dL) | 2.83 (1.29 to 6.21) | 3.15 (1.38 to 7.18) | 3.15 (1.38 to 7.18) | 3.24 (1.40 to 7.48) |
| ≥95th percentile (>74.3 mg/dL) | 4.48 (1.64 to 12.22) | 3.66 (1.27 to 10.51) | 3.66 (1.27 to 10.51) | 3.46 (1.18 to 10.15) |
Data are presented as OR with 95% CI.
Model 1 is unadjusted. Model 2 is adjusted for age and sex. Model 3 adds body mass index, use of antihypertensive medication, smoking and non-high-density lipoprotein cholesterol. Model 4 adds coronary artery calcification.
AVC, aortic valve calcium; Lp(a), lipoprotein(a); UMC, University Medical Centers.