Table 4

Comparisons among prediction models for the risk of atherosclerotic cardiovascular disease events

		c-index (95% CI)	P for difference	NRI (95% CI)	P value	IDI (95% CI)	P value
Model 1	Age
		0.754 (0.747 to 0.761)
Model 2 (vs Model 1)	Model 1+clinical risk factors
Model 2 (vs Model 1)		0.783 (0.776 to 0.790)	<0.001	0.049 (0.016 to 0.081)	0.003	0.008 (0.004 to 0.012)	<0.001
Model 3 (vs Model 2)	Model 2+BMD as a continuous variable
	Lumbar BMD	0.786 (0.780 to 0.793)	0.001	0.028 (0.011 to 0.046)	0.002	0.001 (0.000 to 0.003)	0.140
	Femur neck BMD	0.786 (0.780 to 0.793)	0.005	0.036 (0.017 to 0.055)	<0.001	0.002 (0.001 to 0.004)	0.018
	Total hip BMD	0.790 (0.783 to 0.796)	<0.001	0.036 (0.013 to 0.058)	0.002	0.004 (0.002 to 0.007)	<0.001
Model 4 (vs Model 2)	Model 2+diagnosis of osteopenia or osteoporosis based on the T-score
	Lumbar T-score	0.787 (0.781 to 0.795)	0.003	0.030 (0.009 to 0.052)	0.006	0.002 (0.001 to 0.004)	0.038
	Femur neck T-score	0.790 (0.783 to 0.797)	0.004	0.025 (0.006 to 0.044)	0.008	0.003 (0.001 to 0.005)	0.006
	Total hip T-score	0.793 (0.786 to 0.799)	<0.001	0.039 (0.015 to 0.062)	0.001	0.005 (0.002 to 0.008)	<0.001
	Combined T-score	0.790 (0.784 to 0.797)	<0.001	0.046 (0.024 to 0.068)	<0.001	0.002 (0.001 to 0.004)	0.016

BMD, bone mineral density; CI, confidence interval; IDI, integrated discrimination index; NRI, net reclassification index.