Table 2

Results of the multivariable logistic regression analysis for the entire study population, assessing associations between patient demographics, congenital diagnosis and complexity of cardiac defect, associated cardiac and extracardiac conditions as well as vaccination and medication use and death or adverse clinical outcome

Variable	Time frame considered	All-cause mortality			Death/CPR/MCS/transplantation			Mechanical ventilation/ECLS/CPR/death
Variable	Time frame considered	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
Age (per year)	At admission	1.04	1.04 to 1.04	<0.001	1.03	1.03 to 1.04	<0.001	1.02	1.02 to 1.02	<0.001
No of previous viral pneumonias	At admission
None		Reference			Reference			Reference
1		1.61	1.29 to 2.00	<0.001	1.95	1.60 to 2.37	<0.001	1.88	1.61 to 2.19	<0.001
2		1.46	0.71 to 3.01	0.30	2.10	1.20 to 3.67	0.009	2.64	1.82 to 3.84	<0.001
Female gender		0.71	0.64 to 0.78	<0.001	0.70	0.63 to 0.76	<0.001	0.80	0.74 to 0.85	<0.001
CHD complexity
No CHD		Reference			Reference			Reference
Simple defect		1.10	0.65 to 1.86	0.73	1.78	1.22 to 2.59	0.003	1.99	1.61 to 2.47	<0.001
Moderate complexity		1.20	0.49 to 2.96	0.70	1.76	0.89 to 3.49	0.10	2.52	1.71 to 3.72	<0.001
Complex CHD		2.20	0.95 to 5.08	0.07	3.66	2.00 to 6.69	<0.001	4.87	3.32 to 7.17	<0.001
Chromosomal anomalies	Prior to admission	2.88	1.67 to 4.94	<0.001	2.17	1.37 to 3.44	0.001	1.82	1.35 to 2.45	<0.001
History of cerebral infarction	Prior to admission	1.08	0.93 to 1.25	0.31	1.04	0.90 to 1.20	0.57	0.95	0.83 to 1.08	0.41
History of myocardial infarction	Prior to admission	0.90	0.72 to 1.12	0.33	0.95	0.78 to 1.17	0.66	1.00	0.83 to 1.20	0.97
Diagnosis of heart failure	Prior to admission	1.11	0.92 to 1.33	0.28	1.07	0.89 to 1.28	0.47	1.03	0.88 to 1.20	0.74
History of cancer	Prior to admission	1.45	1.30 to 1.61	<0.001	1.35	1.22 to 1.49	<0.001	1.16	1.06 to 1.27	0.001
Immune disease	Prior to admission	1.07	0.86 to 1.35	0.54	1.07	0.86 to 1.32	0.55	0.98	0.82 to 1.16	0.80
Diabetes	Prior to admission	0.93	0.80 to 1.07	0.33	0.93	0.81 to 1.07	0.33	0.92	0.82 to 1.04	0.20
Obesity	Prior to admission	1.00	0.88 to 1.13	0.96	1.09	0.97 to 1.23	0.14	1.24	1.12 to 1.36	<0.001
Smoking history	Prior to admission	1.24	1.06 to 1.46	0.007	1.32	1.14 to 1.53	<0.001	1.74	1.55 to 1.97	<0.001
History of alcohol abuse	Prior to admission	1.66	1.35 to 2.03	<0.001	1.67	1.38 to 2.02	<0.001	1.60	1.36 to 1.89	<0.001
Severe renal dysfunction	Prior to admission	1.04	0.78 to 1.37	0.80	1.10	0.84 to 1.43	0.49	1.23	0.98 to 1.54	0.07
Severe hepatic disease	Prior to admission	—	—	—	0.92	0.19 to 4.51	0.92	0.77	0.19 to 3.07	0.71
History of cardiac arrhythmias	Prior to admission	0.89	0.78 to 1.01	0.07	0.88	0.78 to 0.99	0.04	0.87	0.78 to 0.96	0.007
Arterial hypertension	Prior to admission	0.98	0.85 to 1.11	0.71	0.97	0.85 to 1.10	0.61	1.04	0.94 to 1.16	0.43
Chronic lung disease	Prior to admission	0.76	0.68 to 0.84	<0.001	0.79	0.72 to 0.88	<0.001	0.81	0.74 to 0.87	<0.001
Documented vaccination
Influenza	1 year prior	0.89	0.79 to 0.99	0.04	0.87	0.78 to 0.97	0.02	0.95	0.87 to 1.04	0.28
Pneumococcal disease	5 years prior	0.86	0.73 to 1.01	0.06	0.91	0.78 to 1.05	0.20	0.91	0.81 to 1.04	0.17
Prescription medication
Cardiac medication	Prior to admission	1.20	1.03 to 1.39	0.02	1.20	1.04 to 1.38	0.01	1.25	1.12 to 1.40	<0.001
Antidepressant or antipsychotic drugs	Prior to admission	1.31	1.17 to 1.46	<0.001	1.25	1.12 to 1.39	<0.001	1.16	1.06 to 1.27	0.001
Anticonvulsives	Prior to admission	1.24	1.07 to 1.42	0.003	1.30	1.14 to 1.48	<0.001	1.38	1.24 to 1.54	<0.001
NSAIDs	Prior to admission	0.91	0.82 to 1.01	0.08	0.88	0.80 to 0.97	0.01	0.82	0.76 to 0.89	<0.001
Antidiabetics	Prior to admission	1.15	0.98 to 1.35	0.10	1.20	1.03 to 1.40	0.02	1.29	1.13 to 1.48	<0.001
Pulmonary hypertension drugs	Prior to admission	1.18	0.58 to 2.41	0.65	1.04	0.53 to 2.08	0.90	1.31	0.75 to 2.27	0.34
Anticoagulation vitamin K antagonists	Prior to admission	0.99	0.83 to 1.17	0.86	1.00	0.85 to 1.18	0.98	1.02	0.88 to 1.17	0.83
Novel oral anticoagulants	Prior to admission	1.12	0.95 to 1.32	0.18	1.06	0.90 to 1.25	0.46	1.09	0.94 to 1.26	0.25
Antiplatelet drugs	Prior to admission	1.01	0.89 to 1.16	0.84	0.98	0.86 to 1.11	0.72	0.90	0.80 to 1.00	0.06
Immunosuppressant medication	Prior to admission	1.49	1.33 to 1.67	<0.001	1.31	1.18 to 1.46	<0.001	1.19	1.09 to 1.29	<0.001

Significant values are in bold.
CHD, congenital heart disease; CPR, cardiopulmonary resuscitation; ECLS, extracorporeal lung support; MCS, mechanical cardiac support; NSAIDs, non-steroidal anti-inflammatory drugs.