Baseline characteristics
| Prasugrel | Ticagrelor | P value | |
| Patients, n | 2073 | 35 917 | |
| Demographics | |||
| Age, mean±SD | 62.2 (10.2) | 66.5 (11.2) | <0.001 |
| ≥71 years | 434 (25.6) | 13 511 (37.6) | <0.001 |
| ≥75 years | 156 (7.5) | 8069 (22.5) | <0.001 |
| Weight, kg, mean±SD | 85.5 (15.8) | 82.4 (15.8) | <0.001 |
| Weight ≤60 kg | 78 (3.9) | 2513 (7.1) | <0.001 |
| Female sex | 435 (21.0) | 9657 (26.9) | <0.001 |
| Medical history | |||
| Smoking | <0.001 | ||
| Never smoker | 644 (32.1) | 13 150 (37.6) | |
| Previous smoker | 715 (35.6) | 12 464 (35.7) | |
| Current smoker | 648 (32.3) | 9338 (26.7) | |
| Previous MI | 488 (23.5) | 6524 (18.2) | <0.001 |
| History of diabetes mellitus | 500 (24.2) | 7674 (21.4) | 0.003 |
| History of hypertension | 1006 (48.8) | 18 544 (51.8) | 0.008 |
| History of hyperlipidaemia | 616 (29.9) | 8858 (25.0) | <0.001 |
| Previous PCI | 457 (22.1) | 5363 (15.0) | <0.001 |
| Previous CABG | 114 (5.5) | 2002 (5.6) | 0.885 |
| Previous stroke | 90 (4.3) | 2139 (6.0) | 0.002 |
| History of CHF | 88 (4.5) | 1348 (3.8) | 0.136 |
| History of renal failure, on dialysis | 11 (0.5) | 119 (0.3) | 0.131 |
| History of COPD | 88 (4.2) | 1914 (5.3) | 0.032 |
| History of PAD | 71 (3.4) | 1184 (3.3) | 0.750 |
| History of dementia | 2 (0.1) | 86 (0.2) | 0.188 |
| History of cancer* | 28 (1.4) | 750 (2.1) | 0.021 |
| Previous bleeding | 63 (3.0) | 1321 (3.7) | 0.131 |
Results are presented as numbers and percentages unless otherwise indicated.
*Any cancer diagnosis in the last 3 years.
CABG, coronary artery bypass grafting; CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; MI, myocardial infarction; PAD, peripheral artery disease; PCI, percutaneous coronary intervention.