Multivariate Cox regression analysis with CMR-RVpGLS for major adverse cardiac events in patients with stage C or D heart failure with non-ischaemic dilated cardiomyopathy during a 5-year follow-up
| CMR-RVpGLS (%) | HR | 95% CI | P value |
| Model I | 1.16 | 1.02 to 1.31 | 0.02 |
| Model II* | 1.19 | 1.02 to 1.38 | 0.02 |
| Model III | 1.18 | 1.01 to 1.37 | 0.04 |
| Model IV* | 1.19 | 0.98 to 1.43 | 0.06 |
| Model V† with inverse probability weighting | 1.17 | 1.04 to 1.32 | 0.01 |
Model I adjust for: sex, age, BMI.
Model II adjust for: sex, age, BMI, LBBB on EKG, QRS duration, Na+, Cl−, BNP (Box-Cox transformation), Hb, creatinine.
Model III adjust for: sex, age, BMI, LGE, LVEDV, RVEDV, LVpGLS, LVMASS, LVpGCS, RVpGCS.
Model IV adjust for: sex, age, BMI, LBBB on EKG, QRS duration, Na+, Cl−, BNP (Box-Cox transformation), Hb, creatinine, LGE, LVEDV, RVEDV, LVpGLS, LVMASS, LVpGCS, RVpGCS.
*Data on the BNP, age, BMI, creatinine, Na+, Cl−, LBBB on EKG, QRS duration and Hb were missing for 54 (28.1%), 1 (0.5%), 5 (2.6%), 16 (8.3%), 21 (10.9%), 22 (11.4%), 5 (2.6%), 11 (5.7%) and 27 (14.0%) patients, respectively. Multiple imputation was used to account for missing data in the model II and model IV.
†Model V is inverse probability weighting of marginal structure model that the weight account for the covariates same as model IV.
BMI, body mass index; BNP, brain natriuretic peptide; CMR, cardiac magnetic resonance; Hb, haemoglobin; LBBB, left bundle branch block; LGE, late gadolinium enhancement; LVEDV, left ventricular end-diastolic volume; LVMASS, left ventricular mass; LVpGCS, left ventricular peak global circumferential strain; LVpGLS, left ventricular peak global longitudinal strain; RVEDV, right ventricular end-diastolic volume; RVpGCS, right ventricular peak global circumferential strain; RVpGLS, right ventricular peak global longitudinal strain.