Table 1

Characteristics of the study population aged 18–65 years and the characteristics of the FAMCAT derivation cohort aged 16 years or above

Study populationDerivation cohort (Weng et al)17
n (%) or mean (SD)n (%) or mean (SD)*
Total777 1282 228 562
Age (years), mean (SD)†37.2 (11.6)49.5 (16.7)
Age during cholesterol measurement (years), mean (SD)‡§35.7 (10.8)57 (16.3)
Gender, n (%)
 Male372 471 (47.9)1 083 539 (48.6)
 Female404 657 (52.1)1 145 023 (51.4)
Ethnicity, n (%)Not available
 White308 694 (39.7)
 South Asian201 957 (26.0)
 Black104 138 (13.4)
 Other60 601 (7.8)
 Unknown¶101 738 (13.1)
IMD (national quintiles), n (%)Not available
 Quintile 1 (least deprived)5555 (0.7)
 Quintile 216 318 (2.1)
 Quintile 350 812 (6.5)
 Quintile 4323 883 (41.7)
 Quintile 5 (most deprived)379 446 (48.8)
Lipid profile, mean (SD)
 Highest total cholesterol recorded, mmol/L**5.3 (1.2)5.8 (1.3)
 Highest LDL cholesterol recorded, mmol/L††3.5 (1.1)3.6 (1.1)
 Triglycerides during cholesterol measurement, mmol/L‡‡§§ 1.7 (1.3)1.7 (1.2)
Lipid-lowering drug usage at time of cholesterol measurement, n (%)
 Prescribed fibrate, bile acid sequestrant or nicotinic acid730 (0.1)9817 (0.4)
 Prescribed low-potency statin754 (0.1)37 799 (1.7)
 Prescribed medium-potency statin21 344 (2.8)125 315 (5.6)
 Prescribed high-potency statin33 034 (4.3)35 582 (1.6)
Family history, n (%)
 Family history of familial hypercholesterolaemia3440 (0.4)12 985 (0.6)
 Family history of raised cholesterol10 176 (1.3)8796 (0.4)
 Family history of myocardial infarction152 155 (19.6)71 596 (3.2)
Pre-existing coronary heart disease, n (%)7950 (1.0)Not available
Premature onset coronary heart disease (<60 years), n (%)6444 (0.8)Not available
Current smoker, n (%)157 549 (20.3)Not available
Diabetes, n (%)42 844 (5.5)285 765 (12.8)
Hypertension, n (%)59 215 (7.6)Not available
Familial hypercholesterolaemia, n (%)16 573 (2.1)Not available
Stroke TIA, n (%)3500 (0.5)Not available
Kidney disease, n (%)11 629 (1.5)261 458 (11.7)
  • *Clinical characteristics presented in the derivation cohort for men and women were combined using the formula for combining summary statistics across two groups in Cochrane Handbook for Systematic Reviews of interventions.24

  • †Median (IQR): 35.0 (28.0–45.0).

  • ‡Median (IQR): 34.0 (28.0–42.0).

  • §Patient’s age at the time of data extraction was used where cholesterol is missing.

  • ¶Unknown ethnic group=not stated code or missing.

  • **Data missing/outlying for 467 007 (60.1%) of 777 128 patients.

  • ††Data missing/outlying for 514 876 (66.3%) of 777 128 patients.

  • ‡‡Data missing/outlying for 521 584 (67.1) of 777 128 patients.

  • §§Median (IQR): 1.3 (0.9–3.1).

  • FAMCAT, Familial Hypercholesterolaemia Case Ascertainment Tool; IMD, Index of Multiple Deprivation; LDL, low-density lipoprotein; TIA, transient ischaemic attack.