Association of VHD and either aortic sclerosis or mitral annular calcification with all-cause mortality
| Aortic sclerosis or mitral annular calcification | |||||||||
| No/early | Advanced | ||||||||
| N | n | HR (95% CI) | P value | N | n | HR (95% CI) | P value | ||
| Crude model | |||||||||
| VHD | No | 1711 | 144 | 1.00 (reference) | 40 | 8 | 2.85 (1.40 to 5.82) | 0.004 | |
| Mild | 1512 | 166 | 1.46 (1.16 to 1.82) | 0.001 | 66 | 19 | 4.46 (2.76 to 7.20) | <0.001 | |
| Significant | 166 | 17 | 1.90 (1.14 to 3.15) | 0.013 | 16 | 7 | 13.7 (6.39 to 29.5) | <0.001 | |
| Multivariable model* | |||||||||
| VHD | No | 1711 | 144 | 1.00 (reference) | 40 | 8 | 2.28 (1.11 to 4.66) | 0.024 | |
| Mild | 1512 | 166 | 1.18 (0.93 to 1.49) | 0.17 | 66 | 19 | 2.88 (1.77 to 4.69) | <0.001 | |
| Significant | 166 | 17 | 1.23 (0.73 to 2.06) | 0.44 | 16 | 7 | 4.38 (1.99 to 9.67) | <0.001 | |
*Multivariable model was adjusted for sex, age, smoking status, index of multiple deprivation, rheumatic fever and atrial fibrillation.
N, number at risk of death within category; n, number of deaths within category; VHD, valvular heart disease.