Unadjusted and adjusted analyses of the relationship between moderate alcohol excess and cardiac structure and function
| Phenotype | Unadjusted analysis | Adjusted analysis | ||
| Estimate and 95% CIs | P value | Estimate and 95% CIs | P value | |
| Indexed left atrial volume (mL/m2) | 5.9 (0.4 to 11.5) | 0.035 | 3.0 (−3.7 to 9.7) | 0.38 |
| Indexed left ventricular end diastolic volume (mL/m2) | 8.3 (0.1 to 16.4) | 0.048 | 4.3 (−4.6 to 13.2) | 0.34 |
| Left ventricular ejection fraction (%) | −3.3 (−6.0 to −0.6) | 0.017 | −3.2 (−7.3 to 1.0) | 0.13 |
| Indexed left ventricular end systolic volume (mL/m2) | 9.4 (1.0 to 17.9) | 0.028 | 6.7 (−3.6 to 17.0) | 0.20 |
| Indexed left ventricular mass (g/m2) | 6.6 (1.5 to 11.7) | 0.012 | 2.4 (−5.5 to 10.2) | 0.55 |
| Indexed right ventricular end diastolic volume (mL/m2) | 5.4 (0.4 to 10.4) | 0.034 | −1.0 (−7.5 to 5.5) | 0.76 |
| Right ventricular ejection fraction (%) | −4.9 (−7.8 to −2.0) | 0.0010 | −2.7 (−7.3 to 1.9) | 0.25 |
| Indexed right ventricular end systolic volume (mL/m2) | 6.8 (2.3 to 11.3) | 0.0030 | 1.4 (−4.1 to 7.0) | 0.61 |
Adjusted analyses covariates: age, sex, titin truncating variant status, medication use including beta blockers, ACE inhibitors, aldosterone antagonists, and diuretics.