Clinical characteristics* of the cohort
| Baseline characteristics | Overall (n=5795) | Men (n=2445) | Women (n=3350) | Non-Black (n=4964) | Black (n=831) |
| Age, y | 73±6 | 73±6 | 73±6 | 73±6 | 74±6 |
| Age categories, n (%) | |||||
| Age <75y | 3771 (65.1) | 1534 (62.7) | 2237 (66.8) | 4377 (66) | 494 (59.4) |
| Age 75–84y | 1788 (30.9) | 799 (32.7) | 989 (29.5) | 1502 (30.3) | 286 (34.4) |
| Age ≥85y | 236 (4.1) | 112 (4.6) | 124 (3.7) | 185 (3.7) | 51 (6.1) |
| Second cohort, n (%) | 594 (10.3) | 206 (8.5) | 388 (11.6) | 9 (0.2) | 585 (70.4) |
| Income ≥$16 000/y | 3155 (58.2) | 1595 (68.5) | 1560 (50.5) | 2898 (62.4) | 257 (33.0) |
| Education | |||||
| <High school | 1687 (29.2) | 717 (29.4) | 970 (29.0) | 1316 (26.6) | 371 (44.9) |
| High school | 1566 (27.1) | 557 (22.9) | 1009 (30.2) | 1392 (28.1) | 174 (21.1) |
| >High school | 2525 (43.7) | 1163 (47.7) | 1362 (40.8) | 2244 (45.3) | 281 (34.0) |
| Body mass index, kg/m2 | 26.7±4.7 | 26.9±5.3 | 26.4±3.8 | 26.4±4.5 | 28.5±5.6 |
| Systolic blood pressure, mm Hg | 136±22 | 135±21 | 137±22 | 136±21 | 140±22 |
| Antihypertensive treatment, n (%) | 2734 (47.4) | 1097 (45.1) | 1637 (49.1) | 2212 (44.6) | 522 (64.4) |
| Hypertension, n (%) | 2560 (44.6) | 998 (41.2) | 1562 (47.0) | 2050 (41.4) | 510 (64.7) |
| Diabetes, n (%) | 841 (15.8) | 373 (16.5) | 468 (15.4) | 678 (14.5) | 163 (25.4) |
| Smoking, n (%) | |||||
| Current | 677 (11.7) | 268 (11.0) | 409 (12.3) | 555 (11.2) | 122 (15.2) |
| Former | 2430 (42.2) | 1394 (57.4) | 1036 (31.1) | 2120 (42.8) | 310 (38.6) |
| Never | 2656 (46.1) | 768 (31.6) | 1888 (56.6) | 2284 (46.1) | 372 (46.3) |
| LDL cholesterol, mg/dL | 130±36 | 123±33 | 135±37 | 130±36 | 128±36 |
| HDL cholesterol, mg/dL | 54±16 | 48±13 | 59±16 | 54±16 | 58±15 |
| Triglycerides, mg/dL | 120 (92, 165) | 119 (91, 162) | 121 (93, 166) | 125 (95, 169) | 102 (79, 136) |
| Statin therapy, n (%) | 127 (2.2) | 32 (1.3) | 95 (2.8) | 95 (1.9) | 32 (3.9) |
| Hypercholesterolemia, n (%) | 2947 (52.1) | 1074 (44.9) | 1873 (57.3) | 2542 (52.2) | 405 (51.1) |
| eGFR, mL/min/1.73 m2 | 69±19 | 67±18 | 70±19 | 67±17 | 79±23 |
| Chronic kidney disease, n (%) | 1971 (34.4) | 879 (36.3) | 1092 (33.1) | 1830 (37.1) | 141 (17.8) |
*Presented as mean±SD or median (IQR) for continuous variables, and count (per cent) for categorical variables.
eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; y, years.