Table 2

Outcome data at 12-month follow-up in patients with baseline BMI ≥27 kg/m²

	Baseline		Change at 12 months		Between group difference, mean (95% CI)	P value	WW participants (n=182)
	Intervention (n=280)	Control (n=257)	Intervention (n=280)	Control (n=257)	Between group difference, mean (95% CI)	P value	WW participants (n=182)
Primary outcomes
Body weight, kg	97.8±13.7	96.6±14.2	−2.4±7.1	−0.2±4.6	−2.2 (−3.2 to −1.2)	<0.001	−3.6±7.6
BMI, kg/m²	31.7±3.6	31.2±3.5	−0.8±2.3	−0.1±1.5	−0.7 (−1.1 to −0.4)	<0.001	−1.2±2.5
Secondary outcomes
Body fat percentage, %	33.5±8.5	32.3±8.7	−1.2±7.3	0.3±6.5	−1.6 (−2.9 to −0.3)	<0.05	−1.3±7.5
Waist circumference, cm	111.6±10.1	110±10.2	−3.7±6.8	−1.9±5.4	−2.0 (−3.1 to −1.0)	<0.001	−4.9±7.3
Blood pressure, mm Hg
Systolic	134±18.4	135±17.5	−2.1±19.0	1.9±18.6	−4.1 (−7.3 to −0.9)	<0.05	−2.5±18.6
Diastolic	79±9.6	79±10.3	−0.3±10.9	1.9±11.6	−2.1 (−4.0 to −0.2)	<0.05	−0.3±11.3
Cholesterol, mmol/L
Total cholesterol	4.1±0.9	4.1±1.2	−0.03±0.94	−0.07±1.24	0.04 (−0.15 to ̶ 0.23)	0.67	−0.03±0.87
LDL-C	2.2±0.8	2.2±0.8	0.01±0.85	−0.01±0.90	0.03 (−0.12 to 0.18)	0.68	−0.02±0.78
HDL-C	1.1±0.4	1.2±0.4	0.06±0.34	0.04±0.33	0.02 (−0.04 to 0.08)	0.45	0.10±0.25
Triglycerides	1.5 (1.1 ̶ 2.1)	1.5 (1.1 ̶ 2.0)	−0.14±0.90	−0.05±1.14	−0.09 (−0.27 to 0.09)	0.34	−0.20±0.89
Fasting glucose, mmol/L	5.9 (5.4 ̶ 6.7)	5.9 (5.4 ̶ 6.6)	−0.15±1.64	−0.17±1.43	0.01 (− 0.29 to 0.30)	0.95	−0.19±1.63
HbA1c, mmol/mol	40.9±12.3	40.5±12.5	0.41±10.10	1.66±11.31	−1.78 (−3.77 to 0.20)	0.08	0.77±9.86

Values presented as mean±SD or median (IQR).
BMI, body mass index; HbA1c, glycated haemoglobin; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; WW, weight loss programme.