Table 2

Clinical outcomes at 30 days among patients with MINOCA and MI with obstructive CAD according to clopidogrel dosing

Standard clopidogrel dosing
(n=11 718)
Double clopidogrel dosing
(n=11 574)
Double-dose versus standard-dose clopidogrel
HR (95% CI)
P valueP value for interaction
CV death/MI/stroke
 Overall514 (4.4)481 (4.2)0.93 (0.82 to 1.05)0.247
 MINOCA5 (0.6)17 (2.1)3.57 (1.31 to 9.76)0.0130.011
 MI with obstructive CAD509 (4.7)464 (4.3)0.91 (0.80 to 1.03)0.126
CV death
 Overall243 (2.1)236 (2.0)0.93 (0.78 to 1.12)0.451
 MINOCA2 (0.3)7 (0.9)3.72 (0.74 to 18.83)0.1120.116
 MI with obstructive CAD241 (2.2)229 (2.1)0.91 (0.76 to 1.10)0.334
All-cause death
 Overall260 (2.2)251 (2.2)0.93 (0.78 to 1.11)0.404
 MINOCA2 (0.3)8 (1.0)4.17 (0.83 to 20.92)0.0820.075
 MI with obstructive CAD258 (2.4)243 (2.3)0.91 (0.76 to 1.08)0.283
MI
 Overall270 (2.3)231 (2.0)0.86 (0.72 to 1.03)0.102
 MINOCA3 (0.4)5 (0.6)1.99 (0.45 to 8.74)0.3620.367
 MI with obstructive CAD267 (2.5)226 (2.1)0.86 (0.72 to 1.02)0.085
Recurrent ischaemia
 Overall55 (0.5)49 (0.4)0.91 (0.62 to 1.33)0.615
 MINOCA0 (0.0)4 (0.5)0.9970.971
 MI with obstructive CAD55 (0.5)45 (0.4)0.83 (0.56 to 1.23)0.362
All strokes
 Overall59 (0.5)59 (0.5)1.00 (0.70 to 1.44)0.997
 MINOCA1 (0.1)6 (0.8)8.63 (0.88 to 84.29)0.0640.084
 MI with obstructive CAD58 (0.5)53 (0.5)0.92 (0.63 to 1.33)0.648
Minor bleeding
 Overall506 (4.3)597 (5.2)1.20 (1.06 to 1.35)0.003
 MINOCA26 (3.4)28 (3.5)1.09 (0.64 to 1.86)0.7560.667
 MI with obstructive CAD480 (4.4)569 (5.3)1.20 (1.07 to 1.36)0.003
Severe bleeding
 Overall182 (1.6)220 (1.9)1.23 (1.01 to 1.49)0.042
 MINOCA4 (0.5)4 (0.5)1.01 (0.23 to 4.36)0.9880.787
 MI with obstructive CAD178 (1.6)216 (2.0)1.23 (1.01 to 1.50)0.040
Major bleeding
 Overall238 (2.0)294 (2.6)1.25 (1.05 to 1.48)0.010
 MINOCA5 (0.7)5 (0.6)0.99 (0.27 to 3.59)0.9870.753
 MI with obstructive CAD233 (2.1)289 (2.7)1.26 (1.06 to 1.49)0.010
  • Data are number (%).

  • CAD, coronary artery disease; CV, cardiovascular; MI, myocardial infarction; MINOCA, myocardial infarction with non-obstructive coronary arteries.