Table 1

Baseline characteristics according to antiplatelet agent

P2Y12iAspirinP value
N=297N=778
Age—mean±SD (year)74.6±7.974.2±8.20.489
≥75 years—no. (%)155 (52.2)406 (52.2)1
Male sex—no. (%)235 (79.1)615 (79.0)1
BMI—mean±SD (kg/m2)24.1±3.424.6±3.80.071
Current smoker—no. (%)42 (14.1)98 (12.6)0.543
Type of AF—no. (%)0.178
 Paroxysmal163 (54.9)397 (51.0)
 Persistent37 (12.5)132 (17.0)
 Permanent97 (32.7)249 (32.0)
Hypertension—no. (%)255 (85.9)659 (84.7)0.702
Diabetes—no. (%)125 (42.1)324 (41.6)0.945
Dyslipidaemia—no. (%)219 (73.7)512 (65.8)0.013
Angina—no. (%)204 (68.7)493 (63.4)0.116
Heart failure—no. (%)100 (33.7)283 (36.4)0.434
Previous stroke—no. (%)58 (19.5)110 (14.1)0.038
Previous myocardial infarction—no. (%)100 (33.7)280 (36.0)0.521
Previous peripheral arterial disease—no. (%)29 (9.8)39 (5.0)0.007
Previous PCI—no. (%)244 (82.2)516 (66.3)<0.001
Type of stent—no./total no. (%)<0.001
 Bare-metal30/239 (12.6)138/459 (30.1)
 Drug-eluting191/239 (79.9)272/459 (59.3)
 Both types13/239 (5.4)19/459 (4.1)
 Unknown5/239 (2.1)30/459 (6.5)
Previous CABG—no. (%)22 (7.4)102 (13.1)0.010
Initial dose of rivaroxaban—no. (%)0.452
 10 mg/day127 (42.8)364 (46.8)
 15 mg/day167 (56.2)407 (52.3)
Use of PPI—no. (%)191 (64.3)482 (62.0)0.482
CHADS2 score—median220.327
CHA2DS2-VASc score—median440.288
HAS-BLED score—median220.018
CrCl
 Mean±SD—mL/min61.5±24.362.0±23.70.534
 Distribution—no./total no. (%)0.375
 <30 mL/min13/277 (4.7)45/732 (6.1)
 30 to <50 mL/min85/277 (30.7)196/732 (26.8)
 ≥50 mL/min179/277 (64.6)491/732 (67.1)
Months since PCI—median (IQR)(month)32.3 (16.5–64.3)63.7 (30.6–112.8)<0.001
  • *Comparisons of the P2Y12i and aspirin groups by the Wilcoxon rank sum test, Fisher’s exact test or the χ2, as appropriate.

  • AF, atrial fibrillation; BMI, body mass index; CABG, coronary artery bypass grafting; CHADS2, Congestive heart failure, Hypertension, Age>75, Diabetes mellitus, and prior Stroke or transient ischaemic attack score; CHA2DS2-VASc, congestive heart failure, hypertension, age 75 years or older, diabetes mellitus, previous stroke or transient ischaemic attack, vascular disease, age 65 to 74 years, female score; CrCl, creatinine clearance; HAS-BLED, Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly score; PCI, percutaneous coronary intervention; PPI, proton pump inhibitor; P2Y12i, P2Y12 inhibitor.