Table 1

Frequencies and percentages of risk factors for patients with FUH displayed with the results of the survival models

Risk factorFrequencyPercentage (%)Risk factor categorisation in Cox modelUnivariable HR (95% CI)Multivariable HR (95% CI)
Clinical subgroupsClinical subgroups (Ref: other FUH)
FUH with atrial isomerism21814.0FUH with atrial isomerism1.61 (1.09 to 2.38)1.75 (1.14 to 2.70)*
Double inlet left ventricle (DILV)32721.0DILV or DIRV0.52 (0.33 to 0.81)0.49 (0.30 to 0.83)**
Double inlet right ventricle (DIRV)161.0
Tricuspid atresia (TA)45028.9Tricuspid atresia1.19 (0.80 to 1.78)1.22 (0.78 to 1.92)
Tricuspid atresia (interaction) follow-up time0.80 (0.68 to 0.94)0.79 (0.66 to 0.94)**
Mitral atresia (MA)1046.7Mitral atresia1.28 (0.78 to 2.10)1.44 (0.84 to 2.49)
Unbalanced AVSD23615.2Unbalanced AVSD2.74 (1.91 to 3.94)2.75 (1.82 to 4.17)***
Other FUH20613.2
GenderGender (Ref: female)
Male87055.9Male0.91 (0.74 to 1.12)0.94 (0.74 to 1.19)
Female68744.1
Index procedure weight below 2.5 kgIndex procedure weight <2.5 kg (Ref: >2.5 kg)
No135787.2
Yes1137.3Yes1.83 (1.31 to 2.54)1.65 (1.13 to 2.41)*
Missing875.6
EthnicityEthnicity (Ref: non-white)
White105067.4White0.81 (0.65 to 1.02)0.88 (0.68 to 1.14)
Black925.9
Asian28518.3
Mixed70.5
Other724.6
Missing513.3
Antenatal diagnosisAntenatal diagnosis (Ref: none)
No29318.8
Yes122478.6Yes1.22 (0.92 to 1.62)1.03 (0.76 to 1.41)
Missing402.6
Congenital non-cardiac comorbidityCongenital non-cardiac comorbidity (Ref: none)
No128882.7
Yes26917.3Yes1.36 (1.05 to 1.75)0.98 (0.73 to 1.31)
PrematurityPrematurity (Ref: full term)
No144792.9
Yes1107.1Yes1.32 (0.91 to 1.92)0.75 (0.46 to 1.24)
Index procedure acquired comorbidityAcquired comorbidity (Ref: none)
No148695.4
Yes714.6Yes2.88 (2.02 to 4.10)2.71 (1.82 to 4.04)***
Index procedure increased severity of illnessIncreased severity of illness (Ref: none)
No141791.0
Yes1409.0Yes2.32 (1.74 to 3.11)2.31 (1.67 to 3.18)***
Index of Multiple Deprivation (IMD)IMD (Ref: most deprived)
Most deprived53334.2
Second most deprived34522.2Second most deprived0.93 (0.71 to 1.22)0.88 (0.65 to 1.19)
Mid-deprived24015.4Mid-deprived0.77 (0.57 to 1.09)0.74 (0.51 to 1.07)
Second least deprived17111.0Second least deprived0.63 (0.42 to 0.94)0.82 (0.52 to 1.27)
Least deprived15610.0Least deprived0.71 (0.48 to 1.06)0.85 (0.55 to 1.30)
Missing1127.2
  • *P<0.05; **p<0.01; ***p<0.001.

  • AVSD, atrioventricular septal defect; FUH, functionally univentricular heart.