Table 3

Univariable and multivariable analysis of in-hospital mortality

	Univariate analysis				Multivariate analysis
	OR	95% CI		P value	OR	Bootstrap 95% CI		P value
	OR	Inferior	Superior	P value	OR	Inferior	Superior	P value
Age, mean±SD	1.035	1.022	1.049	<0.001	1.020	1.004	1.036	0.015
Nosocomial IE	1.768	1.257	2.485	0.001
Prosthesis	1.196	0.861	1.662	0.286
Comorbidities	2.875	1.998	4.136	<0.001
Staphylococcus aureus	3.466	2.367	5.076	<0.001	1.864	1.121	3.098	0.016
Gram-negative bacilli	1.186	0.586	2.402	0.635
Fungi	1.419	0.406	4.953	0.584
Vegetation	3.276	1.706	6.290	<0.001	3.706	1.619	8.482	0.002
Periannular complication	0.892	0.641	1.240	0.495
LVEF <45%	2.838	1.482	5.433	0.002
Heart failure	2.502	1.731	3.615	<0.001	2.338	1.464	3.732	<0.001
Renal failure	5.269	3.703	7.496	<0.001	2.494	1.596	3.896	<0.001
Septic shock	6.996	4.517	10.833	<0.001	3.535	2.008	6.222	<0.001
Cardiac surgery	0.140	0.096	0.204	<0.001	0.260	0.162	0.416	<0.001
Constant					0.031			<0.001

Area under ROC curve 0.841, 95% CI 0.809 to 0.873.
Hosmer-Lemeshow test p value: 0.631 (good fit of multivariable model).
IE, infective endocarditis; LVEF, left ventricle ejection fraction; ROC, receiver operating curve.