Incidence of first subsequent major adverse outcomes (N=143 702)
| Median time to outcome (years) | Cases | Person-years* | Incidence rate (per 100 person-years) | Adjusted incidence rate ratio† | |
| MACE (all) | 0.18 (0.03–1.59) | 91 706 | 3600 | 25.18 (25.02–25.34) | |
| Men | 0.13 (0.02–1.04) | 55 087 | 1800 | 31.03 (30.77–31.29) | Reference |
| Women | 0.31 (0.04–2.47) | 36 619 | 1900 | 19.62 (19.42–19.82) | 0.58 (0.57–0.59) |
| Coronary heart disease (all) | 0.11 (0.02–0.81) | 66 543 | 3900 | 16.87 (16.74–17.00) | |
| Men | 0.09 (0.02–0.58) | 43 238 | 1900 | 22.29 (22.08–22.50) | Reference |
| Women | 0.17 (0.03–1.29) | 23 305 | 2000 | 11.63 (11.48–11.78) | 0.52 (0.51–0.53) |
| Stroke (all) | 2.54 (0.63–5.83) | 5740 | 7500 | 0.77 (0.75–0.79) | |
| Men | 2.33 (0.52–5.56) | 2546 | 4300 | 0.60 (0.57–0.61) | Reference |
| Women | 2.75 (0.71–6.07) | 3194 | 3200 | 1.00 (0.97–1.04) | 1.22 (1.16–1.29) |
| Peripheral vascular disease (all) | 1.83 (0.35–4.88) | 1624 | 7500 | 0.22 (0.21–0.23) | |
| Men | 1.71 (0.35–4.68) | 901 | 4300 | 0.21 (0.19–0.22) | Reference |
| Women | 1.95 (0.34–5.20) | 723 | 3200 | 0.23 (0.21–0.24) | 0.88 (0.80–0.97) |
| Heart failure (all) | 0.95 (0.14–3.83) | 7905 | 7400 | 1.07 (1.05–1.09) | |
| Men | 0.73 (0.11–3.54) | 3823 | 4300 | 0.90 (0.87–0.93) | Reference |
| Women | 1.22 (0.19–4.11) | 4082 | 3100 | 1.30 (1.26–1.34) | 1.00 (0.96–1.05) |
| Cardiovascular mortality (all) | 0.20 (0.02–3.13) | 9894 | 7600 | 1.29 (1.27–1.32) | |
| Men | 0.21 (0.02–3.06) | 4579 | 4400 | 1.04 (1.02–1.08) | Reference |
| Women | 0.19 (0.02–3.22) | 5315 | 3300 | 1.63 (1.59–1.67) | 0.89 (0.85–0.93) |
| All-cause mortality (all) | 1.37 (0.08–5.07) | 29 503 | 7800 | 3.77 (3.73–3.82) | |
| Men | 1.20 (0.07–4.78) | 13 668 | 4500 | 3.07 (3.02–3.12) | Reference |
| Women | 1.54 (0.08–5.34) | 15 835 | 3400 | 4.71 (4.63–4.78) | 0.92 (0.90–0.94) |
*100 person-years at risk; all: both men and women; follow-up time: median follow-up time in years reported with IQR.
†Incident rate ratio adjusted for age (continuous variable) and Index of Multiple Deprivation (socioeconomic status).
MACE, major adverse cardiovascular events.