Table 2

Comparison of AS-ATTR to older age controls, AS and ATTR using regression analysis

Myocardial factor	Diagnosis	Marginal geometric mean	95% CI	P value
Myocardial factor	Diagnosis	Marginal geometric mean	95% CI	(vs AS+ATTR)
NT-proBNP	AS+ATTR	2844	1745 to 4635	NR
	AS	1294	1077 to 1554	0.002
	ATTR	3272	2552 to 4197	0.63
	Control	127	100 to 162	<0.001
LVMi	AS+ATTR	139	112 to 167	NR
	AS	120	109 to 130	0.179
	ATTR	180	167 to 194	0.013
	Control	92	79 to 106	0.003
MCF	AS +ATTR	0.17	0.13 to 0.22	NR
	AS	0.3	0.27 to 0.33	0.001
	ATTR	0.1	0.09 to 0.11	<0.001
	Control	0.27	0.24 to 0.30	0.017
GLS	AS+ATTR	−15.1	−21.6 to 8.5	NR
	AS	−14.8	−16.5 to 13.1	0.576
	ATTR	−12.2	−13.5 to 10.8	0.215
	Control	−19.5	−20.7 to 18.2	0.002
TAPSE	AS+ATTR	1.5	1.1 to 2.0	NR
	AS	1.9	1.8 to 2.0	0.332
	ATTR	1.5	1.4 to 1.6	0.156
	Control	2.4	2.3 to 2.5	<0.001
hsTnT	AS+ATTR	50	30 to 83	NR
	AS	22	19 to 25	<0.001
	ATTR	49	43 to 56	0.529
	Control	12	10 to 13	<0.001
E/A ratio	AS+ATTR	3.3	0.9 to 5.7	NR
	AS	1.1	0.9 to 1.3	<0.001
	ATTR	2.3	1.9 to 2.8	0.272
	Control	0.7	0.7 to 0.8	<0.001
Carpal tunnel syndrome	AS+ATTR	1.3	1.1 to 1.6	NR
	AS	1	1.0 to 1.0	0.001
	ATTR	1.3	1.2 to 1.4	0.864
	Control	n/a	n/a	n/a

GLS, global longitudinal strain; hsTnT, high-sensitivity troponin T; LVMi, left ventricular mass index; MCF, myocardial contraction fraction; NT-proBNP, N terminal probrain natriuretic peptide; TAPSE, tricuspid annular planar systolic excursion.