Risk of first subsequent major adverse outcome for women compared with men (reference category)
| Cox model HR (95% CI) | Competing risks model* Sub-HR (95% CI) | |
| Model 1† | ||
| Major adverse cardiovascular event | 0.68 (0.67 to 0.69) | 0.71 (0.70 to 0.72) |
| Coronary heart disease | 0.62 (0.61 to 0.63) | 0.64 (0.63 to 0.65) |
| Stroke | 1.25 (1.18 to 1.32) | 1.33 (1.26 to 1.41) |
| Peripheral vascular disease | 0.92 (0.83 to 1.02) | 0.95 (0.86 to 1.06) |
| Heart failure | 1.04 (1.00 to 1.09) | 1.09 (1.04 to 1.14) |
| Cardiovascular-related death | 0.94 (0.90 to 0.98) | 0.99 (0.95 to 1.03) |
| All-cause mortality | 0.96 (0.94 to 0.98) | 1.02 (1.00 to 1.05) |
| Model 2‡ | ||
| Major adverse cardiovascular event | 0.67 (0.66 to 0.68) | 0.69 (0.68 to 0.70) |
| Coronary heart disease | 0.60 (0.59 to 0.61) | 0.62 (0.61 to 0.63) |
| Stroke | 1.26 (1.19 to 1.33) | 1.32 (1.25 to 1.39) |
| Peripheral vascular disease | 0.92 (0.83 to 1.02) | 0.95 (0.85 to 1.05) |
| Heart failure | 1.09 (1.04 to 1.15) | 1.13 (1.07 to 1.18) |
| Cardiovascular-related death | 0.99 (0.95 to 1.03) | 1.02 (0.98 to 1.06) |
| All-cause mortality | 1.05 (1.02 to 1.07) | 1.11 (1.08 to 1.13) |
*Fine and Gray method for subdistribution regression with competing risks.22
†Model 1: adjusted for age (continuous variable).
‡Model 2: adjusted for age (continuous variable), socioeconomic status, smoking status, body mass index, blood pressure, total cholesterol level, history of alcohol problem, diabetes mellitus, dyslipidaemia, cancer, chronic kidney disease, hypertension, atrial fibrillation, depression and a family history of cardiovascular disease.