Study | Aim of the study | Population/methods | Antiplatelet agent | Results | ||
Viecca et al 3 | Assess the effect of administration of antiplatelet therapy on arterial oxygenation and clinical outcomes in patients with severe COVID-19 | 5 patients received antiplatelet drugs/5 controls. Case–control study | 25 µg/kg/body weight tirofiban as bolus infusion, followed by a continuous infusion of 0.15 µg/kg/body weight per minute for 48 hours. Before tirofiban, patients received aspirin 250 mg infusion and oral clopidogrel 300 mg; both were continued at a dose of 75 mg daily for 30 days. | Reduction in A-a O2 gradient of −32.6 mm Hg (61.9, p=0.154), –52.4 mm Hg (59.4, p=0.016) and −151.1 mm Hg (56.6, p=0.011; p=0.047 vs controls) at 24 hours, 48 hours and 7 days after treatment, respectively. PaO2/FiO2 ratio increased by 52 mm Hg (50, p=0.172), 64 mm Hg (47, p=0.040) and 112 mm Hg (51, p=0.036) after 24 hours, 48 hours and 7 days, respectively. | ||
Liu et al 4 | Assess the effect of dipyridamole effects in patients with COVID-19 to study concentrations of D-dimers, lymphocyte and platelet recovery in the circulation, and clinical outcomes | 14 patients received antiplatelet drugs/17 controls. Case–control group. | Dipyridamole 50 mg oral three times per day for 14 consecutive days | Decreased concentrations of D-dimer (p=0.041), increased but statistically not significant lymphocyte (p=0.112) and platelet recovery (p=0.128) in the circulation, and markedly improved clinical outcomes (mechanical ventilation 14.3% vs 11.8%: discharge rate 78.6% vs 41.2%). P value not reported. | ||
Russo et al 5 | Investigate the association between preadmission antiplatelet therapy and occurrence of death and ARDS in patients with COVID-19. | 55 patients received antiplatelet drugs/137 controls. Case–control group. | 44 (22.9 %) aspirin 5 (2.6 %) P2Y12 inhibitor, 6 (3.1 %) dual antiplatelet therapy. Dose not available. |
No benefit in the risk of death. Unadjusted risk ratio=1.00 (95% CI 0.48 to 1.80), p=0.991. Adjusted risk ratio=0.51 (95% CI 0.21 to 1.15), p=0.110. No benefit for the risk of ARDS. Unadjusted risk ratio=0.81 (95% CI 0.54 to 1.28), p=0.530. Adjusted risk ratio=0.58 (95% CI 0.38 to 1.14), p=0.165. | ||
Sivaloganathan et al 6 | Assess the association between preadmission antiplatelet/anticoagulant use and COVID-19 mortality. | 29 patients received antiplatelet drugs/58 controls. Case–control study. | 18 (62%) aspirin, 8 (28%) clopidogrel, 3 (10%) aspirin+clopidogrel. Dose not available. | No benefit in mortality with antiplatelet drugs (p=0.516). No benefit in mortality with aspirin (p 0.62). | ||
Pan et al 7 | Assess the association between pre-hospitalisation antiplatelet medication use and COVID-19 disease severity. | 239 patients received antiplatelet drugs/534 controls | 199 (83.3%) aspirin, 9 (3.8%) clopidogrel, 1 (0.4%) ticagrelor. (12.6%) DAPT, of which 24 (80.0%) aspirin and clopidogrel, 5 (16.7%) aspirin and ticagrelor, 1 (3.3%) aspirin and prasugrel. Dose not available. | No benefit in disease severity based on MOS. | ||
Peak MOS | OR | 95% CI | ||||
6 vs 5–2 | 1.13 | 0.70 to 1.82 | ||||
6–5 vs 4–2 | 1.02 | 0.66 to 1.57 | ||||
6–4 vs 3–2 | 0.98 | 0.65 to 1.46 | ||||
6–3 vs 2 | 0.88 | 0.55 to 1.41 | ||||
RECOVERY collaborative group8 | Evaluate the outcomes in a randomised controlled study with aspirin and usual care among patients with COVID-19. 1:1 randomisation. | 7351 usual standard of care plus 150 mg aspirin once daily until discharge. 7541 usual standard of care alone. | 7351 patients 150 mg aspirin once daily. | 17% in aspirin group and 17% in usual care died within 28 days (rate ratio 0.96; 95% CI 0.89 to 1.04; p=0.35). Aspirin group have shorter duration of hospitalisation (median 8 vs 9 days) and a higher proportion were discharged from hospital alive within 28 days (75% vs 74%; rate ratio 1.06; 95% CI 1.02 to 1.10; p=0.0062). Aspirin group: absolute reduction in thrombotic events of 0.6% (SE 0.4%) and an absolute increase in major bleeding events of 0.6% (SE 0.2%). |
ARDS, acute respiratory distress syndrome; DAPT, dual antiplatelet therapy; MOS, Modified Ordinal Scale.