Table 1

Baseline patient characteristics

Patient characteristicsAll regions n=37 198Europe n=25 736Asia n=6614Africa/Middle East n=2438South America/Mexico n=2410
Age, years64.2±11.3 (37 198)65.5±11.1 (25 736)60.9±10.9 (6614)*59.6±11.4 (2438)*63.3±10.9 (2410)*
Octogenarians (≥80 years)8.8% (3286/37 198)10.7% (2757/25 736)4.3% (281/6614)*4.2% (102/2438)*6.1% (146/2410)*
Gender, male76.0% (28 257/37 198)75.7% (19 486/25 736)76.3% (5049/6614)79.9% (1947/2438)*73.7% (1775/2410)*
Body mass index, kg/m²27.8±4.6 (29 946)28.1±4.7 (21 612)26.3±4.3 (4735)*28.3±4.6 (1718)*27.8±4.4 (1881)*
≤18.50.7% (222/29 946)0.6% (128/21 612)1.6% (74/4735)*0.5% (8/1718)0.6% (12/1881)
18.5–24.927.7% (8295/29 946)25.5% (5502/21 612)40.1% (1900/4735)*23.0% (395/1718)*26.5% (498/1881)
25–29.944.4% (13 293/29 946)44.9% (9700/21 612)41.2% (1951/4735)*46.1% (792/1718)45.2% (850/1881)
≥3027.2% (8136/29 946)29.1% (6282/21 612)17.1% (810/4735)*30.4% (523/1718)27.7% (521/1881)
Cardiovascular risk factors, n†2.1±0.9 (32 006)2.1±0.9 (22 399)2.0±0.9 (5250)*2.2±1.0 (2231)*2.1±0.9 (2126)
Diabetes mellitus28.4% (10 379/36 572)24.9% (6272/25 192)32.2% (2114/6564)*47.0% (1140/2428)*35.7% (853/2388)*
Insulin dependent20.4% (2121/10 379)20.0% (1255/6272)14.0% (296/2114)*28.1% (320/1140)*29.3% (250/853)*
Non-insulin dependent79.5% (8249/10 379)79.9% (5012/6272)86.0% (1817/2114)*71.7% (817/1140)*70.7% (603/853)*
Unknown0.09% (9/10 379)0.08% (5/6272)0.05% (1/2114)0.3% (3/1140)0.0% (0/853)
Smoking
Never37.0% (12 380/33 480)33.9% (8075/23 848)48.9% (2644/5408)*42.1% (923/2193)*36.3% (738/2031)*
Previous29.0% (9711/33 480)31.1% (7417/23 848)19.9% (1078/5408)*22.3% (490/2193)*35.8% (726/2031)*
Current23.6% (7897/33 480)24.3% (5796/23 848)19.0% (1025/5408)*29.5% (647/2193)*21.1% (429/2031)*
Unknown10.4% (3492/33 480)10.7% (2560/23 848)12.2% (661/5408)6.1% (133/2193)6.8% (138/2031)
Hypertension67.8% (22 840/33 684)66.1% (15 624/23 632)72.4% (4127/5698)*64.1% (1445/2255)78.3% (1644/2099)*
Hypercholesterolemia59.9% (19 462/32 479)61.6% (14 295/23 202)55.1% (2797/5081)*55.6% (1230/2211)*57.4% (1140/1985)*
Family history of heart disease36.2% (7259/20 081)39.5% (5604/14 178)20.7% (678/3274)*35.9% (536/1494)*38.9% (441/1135)
Previous MI22.8% (7852/34 423)21.5% (5239/24 392)28.0% (1601/5727)*20.8% (462/2220)26.4% (550/2084)*
Previous revascularisation29.1% (10 027/34 522)29.2% (7127/24 442)25.6% (1468/5744)*30.9% (695/2253)35.4% (737/2083)*
Previous PCI26.0% (9026/34 687)26.2% (6425/24 559)23.3% (1342/5767)*28.3% (642/2267)*29.5% (617/2094)*
Previous CABG5.6% (1938/34 562)5.7% (1387/24 514)3.3% (191/5745)*6.0% (135/2255)11.0% (225/2048)*
Atrial fibrillation on OAC5.6% (1925/34 450)6.8% (1651/24 359)2.6% (150/5743)*3.0% (69/2283)*2.7% (55/2065)*
Previous stroke5.4% (1879/34 577)5.8% (1415/24 501)5.8% (328/5682)2.6% (60/2314)*3.7% (76/2080)*
Peripheral vascular disease6.7% (2255/33 880)7.3% (1758/23 958)5.1% (286/5655)*5.9% (131/2222)*3.9% (80/2045)*
Congestive heart failure11.36% (3823/33 649)9.5% (2255/23 821)23.6% (1312/5552)*6.1% (136/2242)*5.9% (120/2034)*
Renal impairment7.00% (2548/36 407)6.9% (1731/25 134)8.0% (522/6547)*5.5% (128/2333)*7.0% (167/2393)
Clinical presentation
CCS44.9% (16 672/37 171)44.7% (11 482/25 715)48.4% (3199/6613)*42.0% (1024/2436)*40.2% (967/2407)*
NSTE-ACS35.0% (12 992/37 171)35.7% (9191/25 715)31.2% (2064/6613)*37.6% (915/2436)34.2% (822/2407)
STEMI20.2% (7507/37 171)19.6% (5042/25 715)20.4% (1350/6613)20.4% (497/2436)25.7% (618/2407)*
  • Data are mean±SD for continuous variables with or % (n) for categorical variables. The number of patients with available data is indicated in brackets. The p value for the comparison over all four regions was <0.0001 for all variables.

  • Renal impairment: defined as estimated glomerular filtration rate <60 mL/min/1.73 m². Cardiovascular risk factors include diabetes, current smoking, hypertension, hypercholesterolemia and family history of CV disease

  • *Indicates a p value <0.05 for the difference in characteristics between the region as compared to Europe.

  • †Defines diabetes, current smoking, hypertension, hypercholesterolemia and family history of heart disease.

  • CABG, coronary artery bypass graft; CCS, chronic coronary syndromes; CV, cardiovascular; MI, myocardial infarction; NSTE-ACS, non-ST-segment elevation acute coronary syndrome; OAC, oral anticoagulant; PCI, percutaneous coronary intervention; RCA, right coronary artery; STEMI, ST-segment elevation myocardial infarction.