Incidence rates and rate differences of heart failure (per 1000 person-years) comparing sarcoidosis with the general population, overall and by age at start of follow-up, sex, sarcoidosis treatment status around sarcoidosis diagnosis, time since sarcoidosis diagnosis, and history of ischaemic heart disease or acute myocardial infarction
| Sarcoidosis | General population | Rate difference* (95% CI) | |||
| Events/ N at risk | Incidence rate* (95% CI) | Events/ N at risk | Incidence rate* (95% CI) | ||
| Overall | 204/8574 | 2.2 (1.9 to 2.6) | 721/84 192 | 0.7 (0.7 to 0.8) | 1.5 (1.1 to 1.8) |
| Age at start of follow-up, years | |||||
| 18–44 | 18/3699 | 0.8 (0.5 to 1.3) | 53/36 549 | 0.2 (0.2 to 0.3) | 0.6 (0.2 to 1.0) |
| 45–64 | 68/3394 | 3.3 (2.6 to 4.3) | 225/33 578 | 1.1 (0.9 to 1.3) | 2.2 (1.4 to 3.1) |
| 65–85 | 118/1481 | 19.0 (15.8 to 22.9) | 443/14 065 | 6.6 (5.9 to 7.3) | 12.5 (8.9 to 16.0) |
| Sex | |||||
| Female | 90/3824 | 1.8 (1.4 to 2.4) | 329/37 606 | 0.6 (0.5 to 0.8) | 1.2 (0.8 to 1.6) |
| Male | 114/4750 | 2.4 (2.0 to 3.0) | 392/46 586 | 0.8 (0.7 to 0.9) | 1.6 (1.2 to 2.1) |
| Sarcoidosis treatment around diagnosis† | |||||
| Treated | 62/2696 | 3.0 (2.2 to 4.1) | 161/26 479 | 0.7 (0.6 to 0.9) | 2.3 (1.4 to 3.1) |
| Untreated | 79/3889 | 2.1 (1.6 to 2.8) | 234/38 120 | 0.6 (0.5 to 0.8) | 1.5 (1.0 to 2.0) |
| Time since sarcoidosis diagnosis, years | |||||
| ≤2 | 98/8574 | 1.2 (0.9 to 1.5) | 223/84 192 | 0.5 (0.4 to 0.6) | 0.7 (0.4 to 0.9) |
| >2 | 106/6585 | 1.0 (0.8 to 1.3) | 498/65 949 | 0.2 (0.2 to 0.3) | 0.8 (0.5 to 1.0) |
| History of ischaemic heart disease or acute myocardial infarction | |||||
| Yes | 37/339 | 26.9 (19.4 to 37.4) | 186/2735 | 13.6 (11.5 to 16.1) | 13.3 (4.4 to 22.2) |
| No | 167/8235 | 2.1 (1.8 to 2.5) | 535/81 457 | 0.6 (0.6 to 0.7) | 1.5 (1.1 to 1.8) |
*Rates and rate differences per 1000 person-years were estimated using Poisson regression models adjusted for age, sex (if applicable) and region of residence.
†Evaluated in individuals with start of follow-up from 2006 and onwards for whom medication dispensation data were available in the Prescribed Drug Register.