BMT only (n=40) | BMT+AC (n=80) | Controls (n=80) | P value | |
Age (years) | 50±15 | 53±13 | 50±13 | 0.115 |
Sex | 24M, 16F | 54M, 26F | 44M, 36F | 0.260 |
Body mass index (kg/m2) | 27.1±5.0 | 26.3±4.8 | 25.5±4.4 | 0.205 |
Height (cm) | 172±11 | 172±8 | 169±9 | 0.419 |
Weight (kg) | 76±15 | 73±17 | 74±16 | 0.113 |
Heart rate (bpm) | 70±10 | 69±10 | 67±11 | 0.120 |
BMT to TTE (years) | 6±6 | 6±6 | 0.399 | |
Baseline LVEF by GHPS (%) | 63±5 | 61±7 | 0.023 | |
Conditioning regime | ||||
Myeloablative | 27% | 40% | 0.188 | |
Reduced intensity | 73% | 60% | ||
ECOG status | ||||
0 | 94% | 88% | 0.502 | |
1 | 6% | 12% | ||
NYHA class | ||||
1 | 100% | 96% | 0.719 | |
2 | 0% | 4% |
AC, anthracycline; BMT, bone marrow transplant; ECOG, Eastern Cooperative Oncology Group; GHPS, gated heart pool scan; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association; TTE, transthoracic echocardiogram.